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JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2021, Vol. 23 ›› Issue (3): 359-363.DOI: 10.3969/j.issn.1671-2587.2021.03.015

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Expression and Clinical Value of Serum MiR-633 and MiR-601 in Patients with Early Gastric Cancer

HUANG Ting-ting, PENG Xin, FU Xin, et al   

  1. Danzhou City People's Hospital, Danzhou, Hainan 571799
  • Received:2020-06-08 Online:2021-06-20 Published:2021-06-22

Abstract: Objective To investigate the expression and clinical value of serum microRNA (miR)-633 and miR-601 in patients with early gastric cancer. Methods We enrolled 116 patients with gastric cancer admitted to Danzhou people's hospital, which divided into early gastric cancer group (n=48) and advanced gastric cancer group (n=68) according to the progress of gastric cancer. We also enrolled 50 healthy people as control group. The levels of serum miR-633 and miR-601 detected by real-time quantitative PCR and carbohydrate antigen 72-4 (CA72-4) and carbohydrate antigen 19-9 (CA19-9) detected by chemiluminescence were analyzed. Results The levels of serum miR-633(1.93±0.86 vs. 0.62±0.14), miR-601(9.16±2.50 vs. 3.80±1.27), CA72-4(30.74±7.35 vs. 3.28±0.85,U/mL)and CA19-9(51.38±12.95 vs. 15.60±5.83,U/mL) in gastric cancer group were significantly higher than control group (all were P<0.001). The levels of miR-633(2.58±1.16 vs. 1.24±0.57), miR-601(10.92±3.48 vs. 7.15±1.96), CA72-4(40.52±10.35 vs. 16.65±4.70,U/mL)and CA19-9(64.15±17.42 vs. 36.20±10.18,U/mL)in advanced gastric cancer group were significantly higher than early gastric cancer group (all were P<0.001). The ROC curve showed that the area under curve (0.917, 95%CI: 0.857~0.975) in four indicators combined diagnosis was the largest, with the sensitivity and specificity of 95.7% and 82.6% respectively. Correlation analysis showed that the levels of serum miR-633 and miR-601 were positively correlated with CA72-4 and CA19-9 in early gastric cancer (r=0.760, 0.712, 0.828, 0.725, P<0.001). Conclusion The levels of serum miR-633, miR-601, CA72-4 and CA19-9 are significantly increased in patients with early gastric cancer, and the combined detection of four indexes showed higher diagnostic value in early gastric cancer.

Key words: Early gastric cancer, MiR-633, MiR-601, Combined detection

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