Abstract: Objective To compare the serum chemokine CXCL12/CXCR4 levels between patients with preeclampsia and normal pregnant women, and ananlyze its correlation with abnormal liver function of pregnant women with preeclampsia. Methods 65 patients with preeclampsia （PE group） and 51 normal pregnant women （control group） who underwent cesarean section in the affiliated Maternal and Child Health Hospital of Anhui Medical University from May 2018 to May 2019 were enrolled. Patients in PE group were further divided into mild PE group （23 patients） and severe PE group （42 patients）. We compared general clinical data,serum CXCL12/CXCR4,ALT and AST levels among three groups, and evaluated the correlation between the serum CXCL12/CXCR4 levels and abnormal liver function in pregnant women with preeclampsia and calculate their sensitivity and specificity. ROC curve was used to evaluate the accuracy of this prediction model. Results The gestational age of patients and birthweight of newborns in severe PE group were significantly lower than those in control group and mild PE group （P<0.001）. Pairwise comparison of the maternal serum CXCL12/CXCR4 levels of the control group, mild PE group and severe PE group were statistically different,and gradually decreased （all P<0.017）. The serum ALT of severe PE group was significantly higher than that of mild PE group and control group, while the serum AST of severe PE group and mild PE group was significantly higher than control group（P<0.017）. ROC curve analysis results showed that the area under the ROC curve （AUC） for the diagnosis of preeclampsia was 0.981 with serum CXCL12 as the best cut-off value of 2477.68pg/mL [sensitivity was 92%;specificity was 94% （95%CI： 0.963-0.999）],and AUC was 0.996 withserum CXCR4 as the best cut-off value of 2125.97pg/mL [sensitivity was 95.4%; specificity was 100% （95%CI： 0.960-1.000）]. Spearman correlation analysis showed that maternal serum CXCL12 level was negatively related with ALT（r=-0.486） and AST（r=-0.386）, and CXCR4 level was also negatively related with ALT（r=-0.474）and ASTr=-0.403）（P<0.001）. Conclusion Decreased maternal serum CXCL12/CXCR4 levels are related with preeclampsia and may be involved in the pathogenesis of abnormal liver function in pregnant women with preeclampsia.

Key words: Preeclampsia, CXC chemokine ligand 12, CXC chemokine receptor 4, Alanine aminotransferase, Aspartate aminotransferase