Abstract: Objective To analyze the incidence,clinical features,and risk factors for death of neonatal alloimmune thrombocytopenia（FNAIT）in Chinese population,in order to summarize the epidemiological characteristics of FNAIT in Chinese population and provide support for the development of prevention and control strategies. Methods We retrieved from Medline,PubMed,CBM,CNKI,Wanfang Database,VIP Database and Baidu Academic Search Engine for case reports of FNAIT published from January 1985 to January 2021. The literature was screened according to the inclusion and exclusion criteria,and the literature data was retrospectively analyzed using SPSS 21.0 software.. Results A total of 21 studies were included,involving 36 children. 27 children had positive platelet antibodies,and 9 cases were diagnosed by clinical symptoms and platelet count after exclusion of other thrombocytopenia diseases. Among the children,20 cases were males and 14 cases were females（2 cases were missing）,and the median age of onset was 1 day. There were single fetus in 33 cases and twins in 3 cases. The platelet count of mothers was normal with 17 primiparas and 19 multiparas. The median platelet count in the children was 27.5×10⁹/L,and the clinical manifestations were petechiae,gastrointestinal bleeding and intracranial hemorrhage. After immunoglobulin,glucocorticoid therapy and blood transfusion,2 cases died or died intrauterine（5.9%）. Logistic regression analysis showed that maternal pregnancy and birth history,fetal platelet count, fetal gastrointestinal bleeding and intracranial hemorrhage did not be the risk factors affecting the prognosis of children. Conclusion In China,the incidence of FNAIT is low,and the prognosis of neonatal patients is relatively high after conventional treatment. Routine platelet antibody screening for pregnant women is not recommended.

Key words: Chinese population, Fetal neonatal alloimmune thrombocytopenia, Literature analysis