Abstract: Objective To study the methods for reentry of NAT reactive blood donors to reduce blood scrapping. Methods Blood donors with NAT reactivity and other blood screening non-reactive were selected between 2012 and 2017 in Shanghai Blood Center, and 42 blood donors were recalled to the reentry program. Serological detection methods (ELISA, CLIA) and NAT methods were used to detect the markers (HBV, HCV, HIV and TP). Methods for reentry of ELISA-/NAT+ blood donors were designed. Results In the first reentry, 15 cases were ELISA non-reactive and NAT reactive; 27 cases were ELISA non-reactive and NAT non-reactive. Among 27 cases, 9 cases were anti-HBc/anti-HBe reactive and 14 cases were anti-HBc reactive. Anti-HBc and / or anti-HBe reactive blood donors in the first reentry were still reactive in the second reentry, which suggested those were all deferred permanently in the first reentry. Four reentry cases that were non-reactive to all tests may be eligible for reentry. Conclusion We studied the feasibility of reentry of NAT reactive blood donors and preliminarily determined the reentry rule.

Key words: NAT reactive, Reentry of blood donors, Reentry program