Abstract: Objective To detect platelet antibody in children with autoimmune thrombocytopenia and explore its correlation with autoimmune disorders. Methods The results of platelet antibody were retrospectively analyzed in children with autoimmune diseases of Shanghai Children's Medical Center from January 2018 to December 2020 and the results were statistically analyzed by Graphpad prism 8 statistical software. Results In 94 children with autoimmune diseases, the positive rate of platelet antibody was 50%, the positive rate of autoantibody was 36%, and the positive rate of platelet antibody was higher than that of autoantibody. There was correlation between platelet antibody and autoantibody, but no significant difference between them in autoimmune diseases, according to statistical analysis. Conclusion In the advanced stage of autoimmune disorders, platelet antibodies and autoantibodies can exist simultaneously, both of which are the causes of autoimmune thrombocytopenia.

Key words: Platelet antibody, Autoimmune diseases, Tolerance, Autoimmune thrombocytopenia