Abstract: Objective Analysis of the effect of relevant indexes on blood transfusion of liver transplantation patients. Methods To retrospectively analyze the clinical data of patients undergoing liver transplantation due to various liver diseases in our hospital in 2020,the patients were divided into blood transfusion group（n=153）and non-transfusion group（n=30）according to whether they were transfused with blood products during the operation. According to the diagnostic criteria,these patients were divided into liver cirrhosis group, liver failure group,liver cancer group and other liver diseases group. Intraoperative blood loss,operative time and infusion volume of various blood products （red blood cells,fresh frozen plasma,frozen plasma,cryoprecipitate coagulation factor）of liver transplantation patients were observed. Then,the analysis of preoperative and postoperative coagulation indexes including PT,APTT,INR,FIB in the 153 patients received blood transfusion was performed. Results Compared with the no transfusion group,serum AST,TBIL,Cr,INR and intraoperative blood loss of patients in transfusion group were higher（P<0.05）, but the hemoglobin levels was lower（P<0.05）. There were no significant differences in other indexes（P>0.05）. The intraoperative blood loss and operative time of patients were significantly higher in liver failure group than in the other groups（P<0.05）,as were infusion volume of various blood preparations and the rate of poor prognosis（P<0.05）. Compared with other groups,the preoperative coagulation indexes including PT,APTT,INR,FIB of patients in liver failure group were significantly higher（P<0.05）. Conclusion Perioperative PT and APTT have a guiding role in the blood transfusion of liver transplantation, and the transfusion rate can affect the prognosis and outcome of the patients. It is necessary to make different blood transfusion plans according to basic diseases and blood test indexes before liver transplantation.

Key words: Liver transplantation, Intraoperative blood transfusion, Intraoperative bleeding, Coagulation function, Transfusion strategy