Abstract: Objective To evaluate the low molecular weight heparin in the treatment of acute exacerbation of chronic obstructive pulmonary disease （AECOPD） complicated with respiratory failure clinical curative effect and influence on blood coagulation function, pulmonary function, myocardial injury index and inflammatory factor expression. Methods 86 cases of AECOPD patients in our hospital from January 2015 to January 2017 were enrolled as the study group, the patients were randomly divided into control group and observation group, the control group received routine treatment, the observation group in the control group treatment at the same time give low molecular weight heparin; after 7d treatment to evaluate and compare the clinical efficacy of two groups, their lung function index, blood coagulation index, inflammatory factors and myocardial damage index were recorded and analysed. Results The total effective rate of the observation group was 97.67%, and that of the control group was 86.05%. The clinical efficacy of the observation group was better than that of the control group, P<0.05. After treatment, the two groups of patients were better improved in pulmonary function, coagulation function indicators, inflammatory factors and myocardial damage indicators compared to before treatment, P<0.05; but after treatment, the observation group patients were better improved than the control group, P<0.05. Conclusion Low molecular weight heparin can improve the clinical efficacy of AECOPD and respiratory failure patients, reduce the expression level of inflammatory factors, improve the pulmonary function and excessive coagulation state, and reduce myocardial injury.

Key words: Chronic obstructive pulmonary disease, Respiratory failure, Low molecular weight heparin, Coagulation function, Pulmonary function, Inflammatory factors, Myocardial injury