Abstract: Objective To investigate whether vascular endothelial cadherin can predict vascular endothelial injury and its relationship with the occurrence and severity of hemolysis in ABO hemolytic disease of newborn. Methods 50 cases of ABO hemolytic disease of newborn（ABO-HDN Group）and 47 healthy newborns with matching maternal and infant blood types（Control Group）were selected in our hospital from April 2020 to November 2020. The hemoglobin （Hb）, reticulocyte percentage（Ret%）,indirect bilirubin（IBIL）and lactate dehydrogenase（LDH）were measured at the same time, and the concentration of vascular endothelial cadherin（VE-Cad）was quantitatively measured. Results There was no significant difference in birth weight,gestational age and the age by day on detection between the two groups（P> 0.05） ,but there was significant difference in Hb,Ret%,IBIL,LDH and VE-Cad between the two groups（P<0.05）, the VE-Cad level was positively correlated with Ret%,IBIL and LDH,but negatively correlated with Hb（P<0.05）. Multiple regression analysis showed that VE-Cad level was independently correlated with Hb,Ret%,IBIL and LDH （P<0.05）. Conclusion The increased level of VE-Cad in ABO hemolytic disease of newborn can be used to reflect the endothelial injury of children and help to assess the risk of severe vascular dysfunction.

Key words: ABO hemolytic disease of newborn, Vascular endothelial cadherin, Vascular endothelial injury