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JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2021, Vol. 23 ›› Issue (3): 384-388.DOI: 10.3969/j.issn.1671-2587.2021.03.020

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Standardized Nursing of Acute Leukemia Patients with Serious Complications after CAR-T Cell Therapy

ZHANG Jia-si, TAN Fang-fang, YUAN Jia, et al   

  1. The First Affiliated Hospital of Army Medical University (Southwest Hospital), Chongqing 400038
  • Received:2020-07-09 Online:2021-06-20 Published:2021-06-22

Abstract: Objective To summarize the standardized nursing experience of 10 patients with refractory and recurrent acute lymphoblastic leukemia who had serious complications after CAR-T treatment. Methods We closely monitored the patient's body temperature, blood pressure, consciousness, pupil, language performance, convulsion or manifestations of pre-convulsion. The central venous catheter was placed to conduct plasma exchange (PE) timely. Sufficient tocilizumab, glucocorticoid, ventilator and other rescue drugs and equipments were prepared. We kept the patient's respiratory tract unobstructed during loss of consciousness and seizures. Health education and psychological nursing for patients and their families were strengthen. Results 8 patients were recovered and discharged and 2 cases gave up treatments after CRS. No nursing-related complication occurred and we got 100% satisfaction rate from patients. Conclusion Early judgment and nursing intervention could alleviate the complication of CAR-T cell therapy and improve the rescue rate.

Key words: CAR-T cell therapy, Acute lymphoblastic leukemia, Serious complications, Nursing

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