Abstract: Objective To investigate and analyze the time characteristics of occurrence of blood transfusion adverse reactions during infusion of blood components. Methods A total of 985 cases of acute transfusion reactions (ATRs) reported by sentinel of blood safety monitoring of China Blood Transfusion Association were collected, and incidence rate and time of occurrence were analyzed. Results Among ATRs, the reported incidence of adverse reactions associated with platelet transfusion (6.60‰) was much higher than that associated with red blood cell transfusion (1.64‰) and plasma transfusion (1.25‰). The incidence of allergic reactions from blood components transfused (1.24‰) was higher than that of febrile non-hemolytic transfusion reaction (FNHTR) (0.63‰) and other reactions. The time of occurrence of transfusion reactions showed right-skewed distribution. The occurrence of adverse reaction of red blood cell transfusion was distributed in the first 140 minutes, accounting for 79.56%, and many adverse reactions still occurred after 180 minutes of transfusion. The adverse reaction of plasma transfusion mainly occurred in the first 60 minutes, accounting for 56.92%. The adverse reaction of platelet transfusion mainly occurred from 20 minutes to 100 minutes, accounting for 80.33%, with the number of cases varied greatly across different time. Allergic reactions occurred rapidly, of which mostly occurred during 30 to 60 minutes after transfusion. FNHTR occurred relatively slowly, and the number of cases of certain blood components transfusion showed peaks at different time periods. Conclusion The incidence of adverse reactions associated with blood component transfusion varied, and the time of occurrence had its own characteristics. Understanding the pattern in occurrence time can guide clinical transfusion practice and fully ensure the safety of blood recipients.

Key words: Haemovigilance, Transfusion reaction, Time analysis, Incidence, Acute transfusion reaction