Abstract: Objective To retrospectively analyze the coagulation and myocardial markers of patients infected with different Omicron variants in spring and winter in Shanghai during 2022. Method A total of 1 388 patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from April 18, 2022 to May 15, 2022 (spring strain group, BA.2 variant) and from December 14, 2022 to January 31, 2023 (winter strain group, BA.5 and BF.7 variants) were collected. Prothrombin time (PT), activated partial thromboplastin time (APTT), DD dimer (DD), fibrinogen degradation products (FDP), antithrombin Ⅲ (AT Ⅲ), high sensitivity troponin I (hsTnI), myoglobin (MYO), cardiac kinase isoenzyme MB (CK-MB) and hsTnT were measured in 1 388 patients (974 cases in spring strain group and 414 cases in winter strain group). Results The levels of DD, FDP, hsTnI, MYO hsTnT and CK-MB were significantly higher and the activity of AT Ⅲ was significantly lower in patients infected with winter strain than those infected with spring strain (P<0.01). While APTT was not statistically significant (P>0.05). Conclusion The clinical characteristics of patients infected with different Omicron variants are different. Paying attention to the laboratory markers in time can provide laboratory basis for the diagnosis and treatment of COVID-19.

Key words: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), Omicron, Variants, Coagulation markers, Myocardial markers