Abstract: Objective To investigate the effects of plasmapheresis on donor serum proteins and electrolytes to provide scientific basis for the health and safety of plasma donors. Methods A total of 223 new plasma donors were recruited from two plasmapheresis stations in Sichuan Province from February to May 2022, of which 118 donors were enrolled. The demographic information of donors was collected and followed up for one year. The plasma proteins and electrolytes levels were detected before each plasma donation. The change trend of plasma proteins and electrolytes levels was analyzed, and the covariance analysis was used to eliminate the interference of the baseline level of each relevant index before donation. The influence of donation times on the change of relevant indicators after donation was analyzed, and multiple linear regression was used to explore the influencing factors of relevant indicators. Results The levels of serum ferritin (SF) in male donors decreased with the increase of donation times, while the levels of other components did not fluctuate significantly. After controlling for confounding factors by covariance analysis, there was no statistical significance in the influence of donor times on SF. The results of multiple linear regression showed that the effect of donation times on SF level was not statistically significant after controlling the baseline level. Conclusion Low frequency plasma donation over a period of one year did not have statistically significant effects on plasma proteins and electrolyte levels in donors.

Key words: Plasmapheresis, Ferritin, Plasma proteins, Electrolyte, Follow-up study