Research Progress in the Relationship of Apheresis Donation to Bone Metabolism and Bone Mineral Density

doi:10.3969/j.issn.1671-2587.2023.01.024

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2023, Vol. 25 ›› Issue (1): 143-148.DOI: 10.3969/j.issn.1671-2587.2023.01.024

Research Progress in the Relationship of Apheresis Donation to Bone Metabolism and Bone Mineral Density

LI Wan, WANG Ya, XIAO Guang-lin, et al

Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu 610052

Received:2022-11-07 Published:2023-02-20

Abstract

Abstract: Apheresis donation is an important source of clinical blood and raw materials for blood products. Changes in electrolyte levels and loss of blood components caused by long-term apheresis donation are related to bone density and bone metabolism. Therefore, there is growing concern about whether apheresis donation as a mode of behavior has any impact on bone metabolism and bone density. In this paper, the correlation of apheresis donation with bone metabolism and bone density as well as the potential mechanisms are summarized and discussed from the three aspects of calcium balance, iron metabolism and lipid metabolism, in order to provide a basis for ensuring the health and safety of component blood donors.

Key words: Apheresis donation, Plasmapheresis, Plateletpheresis, Bone mineral density osteoporosis

CLC Number:

R457

LI Wan, WANG Ya, XIAO Guang-lin, et al. Research Progress in the Relationship of Apheresis Donation to Bone Metabolism and Bone Mineral Density[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(1): 143-148.

References

[1] 李军,程丹凤.单采血小板采集过程中发生聚集情况1例[J].现代医药卫生,2020,36(7):1114-1116.
[2] 国家卫生健康委员会.2019年国家血液安全报告[M].北京:人民卫生出版社,2022.
[3] OKAFOR C,WARD D M,MOKRZYCKI M H,et al.Introduction and overview of therapeutic apheresis[J].J Clin Apher,2010,25(5):240-249.
[4] LEE G,AREPALLY G M.Anticoagulation techniques in apheresis:from heparin to citrate and beyond[J].J Clin Apher,2012,27(3):117-125.
[5] 赵宏祥,汪玲,胥琳琳,等.献血者多次单采血小板对其血清生化指标及血液流变学的影响[J].中国输血杂志,2012,25(11):1199-1200.
[6] 沈燕,叶盛,傅强.献血频次对单采血小板献血者血清钙、镁和甲状旁腺素的影响[J].临床输血与检验,2021,23(4):469-472.
[7] 王瑞,葛红卫,郭瑾,等.单采血小板献血者铁蛋白状况调查与分析[J].中国输血杂志,2021,34(1):8-12.
[8] 褚晓凌,侯建明,林豪,等.柠檬酸盐抗凝剂对献血者骨代谢平衡的短期影响[J].中国实验血液学杂志,2010,18(3):785-789.
[9] FENG X,MCDONALD J M.Disorders of bone remodeling[J].Annu Rev Pathol,2011,6:121-145.
[10] WU C H,CHANG Y F,CHEN C H,et al.Consensus statement on the use of bone turnover markers for short-term monitoring of osteoporosis treatment in the Asia-Pacific region[J].J Clin Densitom,2021,24(1):3-13.
[11] 夏维波, 章振林, 林华, 等.原发性骨质疏松症诊疗指南(2017)[J].中国骨质疏松杂志, 2019, 25(3): 281-309.
[12] RYAN C W,HUO D Z,BYLOW K,et al.Suppression of bone density loss and bone turnover in patients with hormone-sensitive prostate cancer and receiving zoledronic acid[J].BJU Int,2007,100(1):70-75.
[13] 许闫严,张克良,魏忠民,等.雌激素对去势骨质疏松症大鼠骨密度和骨代谢影响的实验研究[J].中国骨质疏松杂志,2018,24(6):776-780.
[14] WANG J,ZHOU J,CHENG C M,et al.Evidence supporting dual,IGF-I-independent and IGF-I-dependent,roles for GH in promoting longitudinal bone growth[J].J Endocrinol,2004,180(2):247-255.
[15] VESTERGAARD P,MOSEKILDE L.Fractures in patients with hyperthyroidism and hypothyroidism:a nationwide follow-up study in 16,249 patients[J].Thyroid,2002,12(5):411-419.
[16] CANALIS E,DELANY A M.Mechanisms of glucocorticoid action in bone[J].Ann N Y Acad Sci,2002,966:73-81.
[17] 田路. 糖尿病患者糖代谢与骨代谢的关系研究[D].合肥:安徽医科大学,2016.
[18] 刘勇. 绝经前后女性血清瘦素与骨密度相关性的Meta分析[D].天津:天津医科大学,2018.
[19] 王啸. “铁蓄积”影响骨代谢的临床观察及分子机制[D].苏州:苏州大学,2018.
[20] 程千,刘起富,金铭,等.绝经后女性铁蓄积与骨代谢及机体炎症反应的相关性研究[J].中国骨质疏松杂志,2019,25(5):649-655.
[21] 杨娟,徐瑾.绝经后骨质疏松症患者血清铁调素水平变化及临床意义[J].检验医学,2019,34(1):23-27.
[22] 刘叶青. 血清铁蛋白与绝经后骨质疏松症的相关性分析[D].石家庄:河北医科大学,2020.
[23] 乔铭薪,朱舟,万乾炳.高胆固醇对骨代谢影响的研究进展[J].中国骨质疏松杂志,2021,27(11):1632-1636.
[24] 贾小玥,郑黎薇,袁泉,等.肠道菌群:绝经后骨质疏松防治新靶点[J].中国骨质疏松杂志,2017,23(3):392-401.
[25] 李金桥. 睡眠时间与骨密度的相关性研究[D].兰州:兰州大学,2019.
[26] 贾易臻,谷福顺,王爱国.睡眠与骨质疏松症相关性研究进展[J].中国骨质疏松杂志,2021,27(3):463-468.
[27] 曹聪. 性别、年龄、生活饮食习惯及运动锻炼习惯对骨密度的影响研究[D].扬州:扬州大学,2016.
[28] 陈颖,Markus Dettke,Paul Hoecker,等.血小板机采过程中年龄依赖性骨代谢变化分析[J].中华检验医学杂志,2007,30(8):878-881.
[29] 陈道全,郑素英,陈青容,等.机采血小板过程引发献血者骨代谢平衡变化的分析[J].中国输血杂志,2011,24(9):772-773.
[30] CHEN Y,BIEGLMAYER C,HÖCKER P,et al.Effect of acute citrate load on markers of bone metabolism in healthy volunteers[J].Vox Sang,2009,97(4):324-329.
[31] CHEN Y,HOU J M,CHEN G L,et al.Calcium supplementation attenuates citrate-related changes in bone metabolism:a placebo-controlled crossover study in healthy volunteers[J].Bone,2011,49(3):506-512.
[32] 国家质量监督检验检疫总局,中国国家标准化管理委员会.献血者健康检查要求:GB 18467—2011[S].北京:中国标准出版社,2012.
[33] 国家卫生健康委.单采血浆站技术操作规程(2022年版)[S], 2022.
[34] AMREIN K,KATSCHNIG C,SIPURZYNSKI S,et al.Apheresis affects bone and mineral metabolism[J].Bone,2010,46(3):789-795.
[35] 孙革,熊恺轩,庄乃保,等.深圳男性高频多次单份机采血小板献血者血清骨代谢生化标志物水平和骨密度情况的研究[J].国际检验医学杂志,2019,40(19):2361-2364.
[36] 徐丽娟,丁思娇,冯学胜,等.献血频次对献血者骨密度影响的观察[J].人民军医,2012,55(7):610-611.
[37] GRAU K,VASAN S K,ROSTGAARD K,et al.No association between frequent apheresis donation and risk of fractures:a retrospective cohort analysis from Sweden[J].Transfusion,2017,57(2):390-396.
[38] BIALKOWSKI W,BLANK R D,ZHENG C,et al.Impact of frequent apheresis blood donation on bone density:a prospective,longitudinal,randomized,controlled trial[J].Bone Rep,2018,10:100188.
[39] KIEL D P,FELSON D T,ANDERSON J J,et al.Hip fracture and the use of estrogens in postmenopausal women.The Framingham Study[J].N Engl J Med,1987,317(19):1169-1174.
[40] 中华人民共和国国家卫生健康委员会.国家卫生健康委员会2018年10月19日媒体沟通会文字实录 [EB/OL].[2018-10-19]http://www.nhc.gov.cn/wjw/xwdt/201810/d816a5c72f6b45e399a1e7214642cd47.shtml.
[41] BIALKOWSKI W,BRUHN R,EDGREN G,et al.Citrate anticoagulation:are blood donors donating bone?[J].J Clin Apher,2016,31(5):459-463.
[42] STEDDON S J,CUNNINGHAM J.Calcimimetics and calcilytics—fooling the calcium receptor[J].Lancet,2005,365(9478):2237-2239.
[43] JEHLE S,HULTER H N,KRAPF R.Effect of potassium citrate on bone density,microarchitecture,and fracture risk in healthy older adults without osteoporosis:a randomized controlled trial[J].J Clin Endocrinol Metab,2013,98(1):207-217.
[44] BOOT C L,LUKEN J S,VAN DEN BURG P J M,et al.Bone density in apheresis donors and whole blood donors[J].Vox Sang,2015,109(4):410-413.
[45] BUCHTA C,MACHER M,BIEGLMAYER C,et al.Reduction of adverse citrate reactions during autologous large-volume PBPC apheresis by continuous infusion of calcium-gluconate[J].Transfusion,2003,43(11):1615-1621.
[46] KRAMER L,BAUER E,JOUKHADAR C,et al.Citrate pharmacokinetics and metabolism in cirrhotic and noncirrhotic critically ill patients[J].Crit Care Med,2003,31(10):2450-2455.
[47] BOLAN C D,CECCO S A,YAU Y Y,et al.Randomized placebo-controlled study of oral calcium carbonate supplementation in plateletpheresis:II.Metabolic effects[J].Transfusion,2003,43(10):1414-1422.
[48] HESTER J P,MCCULLOUGH J,MISHLER J M,et al.Dosage regimens for citrate anticoagulants[J].J Clin Apher,1983,1(3):149-157.
[49] STRAUSS R G.Mechanisms of adverse effects during hemapheresis[J].J Clin Apher,1996,11(3):160-164.
[50] WAWRZYNIAK A,BALAWENDER K.Structural and metabolic changes in bone[J].Animals (Basel),2022,12(15):1946.
[51] KIM K M,CHOI S H,LIM S,et al.Interactions between dietary calcium intake and bone mineral density or bone geometry in a low calcium intake population (KNHANES IV 2008-2010)[J].J Clin Endocrinol Metab,2014,99(7):2409-2417.
[52] LLOYD T,ANDON M B,ROLLINGS N,et al.Calcium supplementation and bone mineral density in adolescent girls[J].JAMA,1993,270(7):841-844.
[53] AL-DAGHRI N M,YAKOUT S,GHALEB A,et al.Iron and 25-hydroxyvitamin D in postmenopausal women with osteoporosis[J].Am J Transl Res,2022,14(3):1387-1405.
[54] 肖光林,王娅,刘欣欣,等.成分血捐献者铁缺乏研究进展[J].中国输血杂志,2022,35(4):470-474.
[55] 单宇,王亮,张敏,等.铁蓄积、骨内血管与骨质疏松关系的研究进展[J].中国骨质疏松杂志,2017,23(7):954-957.
[56] PAGE E A,HARRISON J F,JALDOW E J,et al.Impairment of short-term memory associated with low iron stores in a volunteer multidose plateletpheresis donor[J].Transfus Med,2008,18(5):312-314.
[57] HUANG X,XU Y J,PARTRIDGE N C.Dancing with sex hormones,could iron contribute to the gender difference in osteoporosis?[J].Bone,2013,55(2):458-460.
[58] KIM S M,KIM A S,KO H J,et al.Association between bone mineral density and serum iron indices in premenopausal women in south Korea[J].Korean J Fam Med,2020,41(3):175-182.
[59] 柏林. 铁缺乏对骨形成的影响及相关机制研究[D].苏州:苏州大学,2016.
[60] MEDEIROS D M,STOECKER B,PLATTNER A,et al.Iron deficiency negatively affects vertebrae and femurs of rats independently of energy intake and body weight[J].J Nutr,2004,134(11):3061-3067.
[61] DÍAZ-CASTRO J,LÓPEZ-FRÍAS M R,CAMPOS M S,et al.Severe nutritional iron-deficiency anaemia has a negative effect on some bone turnover biomarkers in rats[J].Eur J Nutr,2012,51(2):241-247.
[62] KIM B J,AHN S H,BAE S J,et al.Iron overload accelerates bone loss in healthy postmenopausal women and middle-aged men:a 3-year retrospective longitudinal study[J].J Bone Miner Res,2012,27(11):2279-2290.
[63] 张林林,郑闽前,徐小卒,等.435名女性体检者血清铁蛋白与骨密度的相关性[J].中华骨质疏松和骨矿盐疾病杂志,2014,7(1):9-14.
[64] 芦晶晶,李星,娄萍萍,等.血清铁蛋白水平与骨密度的相关性研究[J].中华老年骨科与康复电子杂志,2020,6(2):111-116.
[65] HOU J,YAMADA S,KAJIKAWA T,et al.Iron plays a key role in the cytodifferentiation of human periodontal ligament cells[J].J Periodontal Res,2014,49(2):260-267.
[66] MAGUIRE O C,MC CARTHY D,CUNNINGHAM S K.The effect of plasmapheresis on the concentration of certain plasma proteins:a case identified by an inaccurate LDL-cholesterol estimation[J].Ann Clin Biochem,2008,45(Pt 4):436-439.
[67] ZHAO H X,LI X Q,ZHANG D Y,et al.Integrative bone metabolomics-lipidomics strategy for pathological mechanism of postmenopausal osteoporosis mouse model[J].Sci Rep,2018,8(1):16456.
[68] LI H H,CONDON F,KESSLER D,et al.Evidence of relative iron deficiency in platelet- and plasma-pheresis donors correlates with donation frequency[J].J Clin Apher,2016,31(6):551-558.
[69] ZHANG Q,ZHOU J T,WANG Q,et al.Association between bone mineral density and lipid profile in Chinese women[J].Clin Interv Aging,2020,15:1649-1664.
[70] CUI L H,SHIN M H,CHUNG E K,et al.Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal rural women in South Korea[J].Osteoporos Int,2005,16(12):1975-1981.
[71] GARG M K,MARWAHA R K,TANDON N,et al.Relationship of lipid parameters with bone mineral density in Indian population[J].Indian J Endocrinol Metab,2014,18(3):325-332.
[72] YOU L,SHENG Z Y,TANG C L,et al.High cholesterol diet increases osteoporosis risk via inhibiting bone formation in rats[J].Acta Pharmacol Sin,2011,32(12):1498-1504.

Research Progress in the Relationship of Apheresis Donation to Bone Metabolism and Bone Mineral Density

RichHTML

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 7

Recommended Articles

Metrics

Comments

About

Author

Journal

Access Statistics

Contact

[1]	XIAO Guang-lin, WANG Ya, HUANG Jing, et al. Preliminary Analysis of the Influencing of Plasmapheresis Donation on Serum Ferritin Level and Iron Accumulation Rate in People at Risk of Iron Accumulation [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(1): 112-118.
[2]	HU Yan, ZHU Bang-qiang, WEN Hui-qin, et al. Lymphoplasmapheresis in ABO-incompatible Living Donor Kidney Transplantation [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2021, 23(5): 608-611.
[3]	LIAO Hong-mei, MAO Wei, XIANG Yu-pei, et al. Study on the Changes of Blood Biochemical Indicators in Frequent Plateletpheresis Donors with an Interval of 14~16 Days [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2021, 23(5): 652-654.
[4]	SHEN Yan, YE Sheng, FU Qiang. The Effect of Donation Frequency on Serum Calcium, Magnesium and Parathyroid Hormone Levels in Plateletpheresis Donors [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2021, 23(4): 469-472.
[5]	YE Sheng, SHEN Yan, CHEN Jin, et al. Reengineering of Apheresis Donation Site and Workflow during COVID-19 Epidemic [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2020, 22(3): 241-245.
[6]	CHEN Jin-yan, LIN Qi-wen, OU YANG-Jian, et al. Longitudinal Study of Influencing Factors on Peripheral Platelet Count of Plateletpheresis Donor [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2019, 21(4): 375-379.
[7]	HUANG Hui-shan, ZHENG Gui-an, ZHANG Lin. Immature Platelet Count as a Novel Quality Marker in Plateletpheresis [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2018, 20(5): 453-456.