Abstract: Objective To provide a basis for the recruitment and management strategies of donors, we tested whether there were the biochemical changes of blood in donors who plateletpheresis 20 consecutive times and with an interval of 14~16 days, and evaluated the impact of shortening the donation interval. Methods The test results of blood samples taken from donors before plateletpheresis were used as subjects. A total of 42 male cases, aged 25~54, and with an interval of 14~16 days. They were divided into three groups: the test results of the blood samples taken before the first plateletpheresis were used as the control group, and the 10th and 20th test results were used as the observation group 1 and the observation group 2. Blood biochemical tests include: ALT, Alb, TP, Ca, P, Fe and SF. Results Compared with the control group, there was no significant difference in the ALT, Alb, TP, Ca, P and Fe detection results of blood donors between observation group 1 and group 2 (P>0.05). However, there was a statistically significant difference in the SF test results of blood donors among observation group 1 and group 2 and the control group (P<0.05). Conclusion There was no significant change in ALT, Alb, TP, Ca, P, and Fe in male donors who plateletpheresis 20 consecutive times and with an interval of 14~16 days, but the SF would decrease if more than consecutive 10 times.

Key words: Plateletpheresis, Blood biochemical, Blood donors