Abstract: Objective To investigate the effect of multiple apheresis platelet donation on some blood routine indicators and platelet correlation factors in plasma. Methods Sixty cases of multiple apheresis platelets donors who have donated platelets twenty times or more per year were listed as study group. 28 cases of first-time apheresis platelet donors were listed as control group. Before donating apheresis platelet, hemoglobin (HGB), hematocrit (HCT), platelet counts (PLT), cumulative number of blood donations were collected and analyzed. The level of thrombopoietin (TPO), platelet activation factor (PAF), von Willebrand factor (vWF), β-thromboglobulin (β-TG), platlet factor 4 (PF4) in plasma of two groups of blood donors before donation were measured by ELISA. Then those data were analyzed statistically. Results The mean age of the blood donors in study group was higher than that of the control group (P<0.05). By covariance analysis, we found that donors of different ages donated apheresis platelet 20 times or more per year, their peripheral blood HGB, HCT, PLT had no significant difference. Donors with different cumulative donation times donate 20 times or more per year, their peripheral blood PLT was no significant difference (P=0.142), but the donors with cumulative number of 51~100 times blood donation had higher HCT3, PLT3 than the other two groups (P=0.033, P=0.023). Different age and the cumulative number of blood donation had no significant influence in TPO, PAF, vWF, β-TG and PF4 (P>0.05). Conclusions Multiple apheresis platelets donations had no significant impact on peripheral HGB, HCT, and PLT. Also there was no obvious influence in platelet related factors.

Key words: Blood donors, Apheresis platelets, Blood routine, Thrombopoietin