Abstract: Objective To investigate whether the SNP of cytochrome P450 gene is associated with a risk of liver cirrhosis induced by hepatitis B virus (HBV). Methods We screened 10 loci on cytochrome P450 genes from bioinformatics database after literature research, and then collected 255 samples in HBV-related cirrhosis group and 160 samples in healthy group for genotyping by sequencing. Logistic regression and other statistical analyses were used to analyze the relationship between SNP and susceptibility to HBV-related cirrhosis. Results The genotype distribution of all SNP loci was in Hardy-Weinberg equilibrium. The chi-square test showed that only rs3758581 genotype and allele distribution at 10 loci were significantly different between HBV-related cirrhosis group and healthy group. Logistic regression analysis showed that the codominant, additive, dominant and overdominance models at rs3758581 suggested patients with GA genotype had an increased risk of HBV-related cirrhosis. Conclusion The GA genotype heterozygous mutation at rs3758581 on cytochrome P450 gene may increase the risk of HBV-related cirrhosis.

Key words: CYP450 gene, Single-nucleotide polymorphism, HBV-related cirrhosis, rs3758581