Abstract: Objective To investigate the expression and clinical significance of Kidd blood group solute carrier family 14 (SLC14A1) gene in kidney clear cell carcinoma (KIRC). Methods Bioinformatics analysis was used to analyze and evaluate the expression and clinical prognostic value of SLC14A1 in KIRC in combination with SANGERBOX, GEPIA, UALCAN, STRING and other databases. Results Kidd blood group SLC14A1 gene was significantly up-regulated in 4 tumors (P<0.05), and significantly down regulated in 22 tumors (P<0.05). The mRNA expression level of SLC14A1 in KIRC tissues was significantly lower than that in normal tissues (tumor1.35±1.69 vs normal 3.90±2.47, P<0.05). Survival analysis showed that the expression level of SLC14A1 was significantly positively correlated with the overall survival rate of KIRC (P<0.05). Based on univariate Cox and multivariate Cox regression analysis, low expression of SLC14A1 was a prognostic risk factor for KIRC. KEGG enrichment analysis dominates in metabolic pathways. GO enrichment analysis dominates in phagosome acidification, trivalent iron transport and transferrin transport. Conclusion The low expression of Kidd blood group SLC14A1 gene in KIRC is associated with the occurrence, development and poor prognosis of KIRC, which is expected to be used as a possible target for KIRC diagnosis, prognosis judgment and treatment.

Key words: Kidney renal clear cell carcinoma, Kidd blood group, SLC14A1 gene, Bioinformatics, TCGA