Advances in Graphene and Its Derivatives in Bone Tissue Engineering

doi:10.3969/j.issn.1671-2587.2024.01.022

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2024, Vol. 26 ›› Issue (1): 136-144.DOI: 10.3969/j.issn.1671-2587.2024.01.022

Advances in Graphene and Its Derivatives in Bone Tissue Engineering

CHANG Xindai^1,2, SUN Sujing², PENG Dongxin², WANG Xiaohui², ZHANG Zhenlin¹

¹State Key Laboratory of Metastable Materials Science and Technology, School of Materials Science and Engineering, Yanshan University, Qinhuangdao 066004;
²Institute of Health Service and Transfusion Medicine,Academy of Military Medical Sciences,Academy of Military Sciences, Beijing 100850

Received:2023-12-22 Published:2024-03-13

Abstract

Abstract: In recent years, nanomaterials have shown unique advantages in the application of bone tissue engineering materials. Graphene and its derivatives such as graphene oxide, reduced graphene oxide, as representative two-dimensional nanomaterials with excellent mechanical properties, large specific surface area, good electrical conductivity and biocompatibility, are considered to have great potential for bone tissue engineering applications. Herein, the applications of graphene and its derivatives as reinforcement components and drug carriers for novel composite bone engineering scaffolds are reviewed, and application studies based on different animal models are also presented in order to fully validate the osteoinductive effects of graphene and its derivatives. Subsequently, the signalling pathways related to osteogenic differentiation, such as Wnt, MAPK and BMP, were summarized, and their respective roles and the interrelationships among these pathways were clarified, which is of great significance for the elucidation of the regulatory mechanism of osteogenic differentiation.

Key words: Graphene and its derivatives, Mesenchymal stem cells, Osteogenic differentiation, Bone tissue engineering

CLC Number:

R318.08

CHANG Xindai, SUN Sujing, PENG Dongxin, WANG Xiaohui, ZHANG Zhenlin. Advances in Graphene and Its Derivatives in Bone Tissue Engineering[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(1): 136-144.

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Advances in Graphene and Its Derivatives in Bone Tissue Engineering

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