Abstract: Objective To identify transfusion reactions caused by bacterial infections and improve the clinical diagnosis rate. Methods A retrospective analysis of transfusion reactions caused by bacterial contamination of platelet in our hospital from 2021 to 2023 was conducted to summarize the symptoms of transfusion adverse reactions in different patients and learn about their individual differences. Results A total of 11 cases of blood transfusion transmitted bacterial infections, including 6 males and 5 females, most of whom were hematological patients, showed elevated body temperature and persistent high fever in severe blood transfusion reactions. Different patients show different symptoms and signs, and it is easy to be confused with other transfusion reactions. Due to the disease type and pre-transfusion medication, there was no significant difference between leukocyte cells before and after transfusion reaction, and the platelet count increased after transfusion reaction but did not meet the effective transfusion standard. The mean C reactive protein after transfusion reaction was about 2 times that of before transfusion reaction, P>0.05, without statistically significant difference. The mean values of procalcitonin and interleukin-6 tests were 100 times higher than normal. Body temperature increased significantly after the transfusion reaction, with statistically significant differences, P<0.05. Conclusions The clinical symptoms of apheresis platelet-related transfusion-transmitted bacterial infection vary greatly, fever is the main manifestation, the differentiation is relatively difficult, and the relevant infection index can be used as auxiliary diagnosis.

Key words: Transfusion-transmitted bacterial infection, Platelet apheresis, Bacterial contamination, Adverse reactions to blood transfusion