The Role of Nucleated Red Blood Cells in Diagnosis and Prognosis

doi:10.3969/j.issn.1671-2587.2025.06.019

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (6): 859-866.DOI: 10.3969/j.issn.1671-2587.2025.06.019

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The Role of Nucleated Red Blood Cells in Diagnosis and Prognosis

ZHU Yuanyuan, PENG Fang, LI Ning

Department of Blood Transfusion, National Health Commission Key Laboratory of Cancer Proteomics, Xiangya Hospital, Central South University, Changsha 410008

Received:2025-05-26 Published:2025-12-24

Abstract

Abstract: Nucleated red blood cells (NRBCs) are immature precursors of red blood cells that retain their nuclei during the process of erythropoiesis. Under physiological conditions, NRBCs are predominantly present in the peripheral blood of pregnant women and neonates, while they are rarely detected in healthy adults. However, their levels in peripheral blood increase significantly under various pathological conditions, including hematological disorders, infectious diseases, and malignancies. This elevation is closely associated with adverse clinical outcomes, making NRBCs promising candidates as diagnostic biomarkers and prognostic indicators. This article aims to provide a comprehensive review of recent advances in NRBC research, with a focus on their molecular mechanisms in disease progression, as well as their potential applications in clinical diagnosis, treatment monitoring, and prognosis evaluation, thereby offering a new insight and strategy for precision medicine.

Key words: Nucleated red blood cells, Biomarkers, Disease diagnosis, Prognosis assessment

CLC Number:

R446.11

ZHU Yuanyuan, PENG Fang, LI Ning. The Role of Nucleated Red Blood Cells in Diagnosis and Prognosis[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(6): 859-866.

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The Role of Nucleated Red Blood Cells in Diagnosis and Prognosis

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