Study on Correlation between HCY Level and Carotid Artery Related Indicators in the Cases of Acute Ischemic Stroke Complicated with H-type Hypertension

doi:10.3969/j.issn.1671-2587.2019.02.017

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2019, Vol. 21 ›› Issue (2): 173-177.DOI: 10.3969/j.issn.1671-2587.2019.02.017

• Orginal Article • Previous Articles Next Articles

Study on Correlation between HCY Level and Carotid Artery Related Indicators in the Cases of Acute Ischemic Stroke Complicated with H-type Hypertension

WANG Guo-hong, ZHU You-ling, WU Jian-xian, et al

The Third Affiliated Hospital of Anhui Medical University,The First People's Hospital of Hefei,Hefei 230061

Received:2018-12-14 Online:2019-04-20 Published:2019-04-10

Abstract

Abstract: Objective To analyze the correlation between plasma homocysteine (HCY) level and carotid artery related risk indicators (such as carotid atherosclerotic plaque and CIMT) in acute ischemic stroke patients with H-type hypertension. Methods 115 cases of acute ischemic stroke complicated with H-type hypertension were selected as group A,68 cases of acute ischemic stroke complicated with simple hypertension as group B and 110 cases of acute ischemic stroke as group C. Systolic blood pressure,diastolic blood pressure,homocysteine (HCY),blood lipid levels were measured and carotid plaque and CIMT were detected in the three groups; the correlation between blood pressure,HCY level,blood lipid,carotid plaque and CIMT were analyzed. Results There was no significant difference in TC,LDL-C and HDL-C between the three groups (P>0.05); SBP,DBP and TG in group A were higher than those in group B and group C with statistical difference (P<0.05); SBP and DBP in group B were higher than those in group C with statistical difference (P<0.05); there was no significant difference in the distribution of TG in group B and group C (P>0.05). Hcy and CIMT in group A were higher than those in group B and group C (P<0.05),and HCY and CIMT had no statistical difference between group B and group C (P>0.05). Carotid plaque was detected between the three groups as χ²=13.346 (2=13.346) and bilateral P=0.001,and the difference was statistically significant (P<0.05) according to the level of alpha=0.05. Pearson linear correlation analysis showed that HCY level was positively correlated with CIMT and carotid plaque in the cases of acute ischemic stroke complicated with hypertension (r=0.545,P<0.01). Conclusion HCY in the cases of acute ischemic stroke complicated with hypertension are positively correlated with such common carotid artery risk indicators as CIMT and carotid plaque formation. H-type hypertension is an independent risk factor for increased CIMT and plaque formation. Detection of HCY,CIMT and atherosclerotic plaque plays an important role in evaluation and treatment of acute ischemic stroke complicated with H-type hypertension.

Key words: Homocysteine（HCY）, Acute ischemic stroke, H-type hypertension, Carotid plaque, CIMT

CLC Number:

R743.3R54

WANG Guo-hong, ZHU You-ling, WU Jian-xian, et al. Study on Correlation between HCY Level and Carotid Artery Related Indicators in the Cases of Acute Ischemic Stroke Complicated with H-type Hypertension[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2019, 21(2): 173-177.

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Study on Correlation between HCY Level and Carotid Artery Related Indicators in the Cases of Acute Ischemic Stroke Complicated with H-type Hypertension

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