Abstract: Objective To reveal the influence of multimodal analgesia on postoperative cognitive dysfunction and C reactive protein （CPR）,plasma cortisol （Cor）,and IL-10 in orthopedics. Methods One hundred patients were divided into two groups,with 50 in each. The control group was treated with routine epidural analgesia,including 0.2 mg fentanyl,1.0 g tramadol,and 5.0 mg droperidol,mixed with physiological saline in total volume of 100 mL,while the experiment group were given multimodal analgesia,including 400 mg oral Celebrex,with 300 mg ropivacaine,40 mg methylprednisolone,5.0 mg Maca,and 0.5mL epinephrine,adding normal saline to 100 mL. The operation time,blood loss,intraoperative urine volume,POCD incidence,serum CPR,Cor,IL-10,VAS and MMSE score,adverse reactions rate in the two groups were examined and observed. Results No significant difference of operation time,intraoperative blood loss and intraoperative urine volume was noted between the two groups（P>0.05）. The incidence of POCD in the experiment group was significantly lower than that in the control（P<0.05）. The levels of CPR and Cor at 1h and 48h after operation were decreased compared with those of the control（P<0.05）. The IL-10 concentration remained unchanged in the two groups（P>0.05）.The VAS score was decreased（P<0.05） but MMSE score,increased（P<0.05）with less adverse reactions compared to the control（P<0.05）. Conclusion Multimodal analgesia has a remarkable therapeutic role in postoperative analgesia of the orthopedics patients by reducing the incidence of cognitive dysfunction,the expression of inflammatory factors,and complications.

Key words: Multimodal analgesia, Orthopedic surgery, Cognitive dysfunction, C reactive protein, Interleukin-10, Plasma cortisol