Expert Consensus on Interference of anti-CD47 Antibody with Compatibility Test in Chinese

doi:10.3969/j.issn.1671-2587.2025.01.002

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (1): 13-20.DOI: 10.3969/j.issn.1671-2587.2025.01.002

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Expert Consensus on Interference of anti-CD47 Antibody with Compatibility Test in Chinese

Clinical Transfusion Medicine Professional Committee of the Chinese Society of Blood Transfusion

Received:2024-10-19 Published:2025-02-25

Abstract

Abstract: With the continuous discovery of immune checkpoints and development of antibody drugs, the application of antibody drugs in tumors has become more and more widespread. However, some immune checkpoints are expressed not only in tumor cells but also in normal erythrocytes, so the application of such drugs may interfere with the transfusion compatibility test, leading to difficulties in blood matching and delays in transfusion. CD47, also known as Integrin Associated Protein (IAP), is a transmembrane protein expressed on the surface of a variety of cells and key signaling molecule of "Don't eat me". Although some clinical trials of anti-CD47 antibody have encountered challenges in recent years, research and development activity in this area remains active, showing its potential in cancer treatment. The purpose of this consensus is to summarize the interference of CD47 antibody on transfusion compatibility test and recommend methods such as using lack IgG4 anti-globulin and anti-idiotype antibody to remove the interference and provide a guarantee for safe clinical blood transfusion.

Key words: CD47, CD47 antibody, compatibility test, Interference, Anti-idiotype antibody, IgG4-deficient anti-human globulin reagent

CLC Number:

R457R446.6

Clinical Transfusion Medicine Professional Committee of the Chinese Society of Blood Transfusion. Expert Consensus on Interference of anti-CD47 Antibody with Compatibility Test in Chinese[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(1): 13-20.

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Expert Consensus on Interference of anti-CD47 Antibody with Compatibility Test in Chinese

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