Abstract: Dry eye disease (DED) is a multifactorial mediated keratoconjunctivitis sicca, whose main clinical symptoms are dry eyes, blurred vision, burning sensation, etc., if not treated in time, it can lead to vision loss, and in severe cases, be accompanied by severe pain or even blindness, which seriously impacts patients. Blood-derived eye drops are derived from blood and contain a variety of bioactive factors, mimicking the biological activity of natural tears, which can lubricate the surface of the eyeball, promote corneal epithelial repair, and improve ocular surface inflammation, and are used to treat eye diseases caused by various causes. Existing clinical studies have shown that the use of blood-derived eye drops can effectively treat dry eye syndrome by reducing corneal epithelial damage, promoting corneal nerve and cell repair, and increasing tear secretion and goblet cell activity. This paper systematically searched the databases of PubMed, CNKI and Wanfang Data, and the search time period was from the establishment of the database to July 2025. Keywords such as "dry eye syndrome", "blood-derived eye drops", "autologous serum", and "platelet-rich plasma" were used to search in Chinese and English. Published clinical studies (e.g, randomised controlled trials, case series) were included, excluding animal trials, reviews, conference abstracts, and non-monotherapy studies. By conducting a summary analysis of the search results, it aims to provide a scientific reference for its clinical application.

Key words: Blood-derived eye drops, Dry eye syndrome, Serum eye drops, Platelet derivative eye drops