Research Progress on the Clinical Application of Sonoclot Coagulation and Platelet Function Analysis

doi:10.3969/j.issn.1671-2587.2025.05.021

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (5): 727-735.DOI: 10.3969/j.issn.1671-2587.2025.05.021

Previous Articles Next Articles

Research Progress on the Clinical Application of Sonoclot Coagulation and Platelet Function Analysis

GUO Yingying, WANG Yufei, ZHU Xiaoyi, WANG Xiaoning

Department of Blood Transfusion, The First Hospital of Jilin University, Changchun 130021

Received:2025-09-01 Revised:2025-09-11 Online:2025-10-20 Published:2025-10-11

Abstract

Abstract: Sonoclot coagulation and platelet function analysis plays a role in the clinical application of multiple fields. By synthesizing recent literature, this article expounds on the research progress of Sonoclot in coagulation function monitoring of patients with different diseases and efficacy evaluation of coagulation drugs. It discusses the application advantages and limitations of Sonoclot, looks forward to future research directions, and provides new ideas for clinical diagnosis and treatment.

Key words: Sonoclot, Coagulation and platelet function analysis, Coagulation monitoring, Pharmacodynamic evaluation

CLC Number:

R446.11

GUO Yingying, WANG Yufei, ZHU Xiaoyi, WANG Xiaoning. Research Progress on the Clinical Application of Sonoclot Coagulation and Platelet Function Analysis[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(5): 727-735.

References

[1] GANTER M T,HOFER C K.Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices[J]. Anesth Analg,2008, 106(5):1366-1375.
[2] VON KAULLA K N,OSTENDORF P,VON KAULLA E. The impedance machine:a new bedside coagulation recording device[J]. J Med,1975,6(1):73-88.
[3] HARTMANN J,MURPHY M,DIAS J D.Viscoelastic Hemostatic Assays: Moving from the Laboratory to the Site of Care-A Review of Established and Emerging Technologies[J]. Diagnostics. 2020,10(2):118.
[4] KANT S,BANERJEE D,SABE S A,et al.Microvascular dysfunction following cardiopulmonary bypass plays a central role in postoperative organ dysfunction[J]. Front Med,2023,10:1110532.
[5] 高顺利,薛玉良,王洪武. Sonoclot分析仪在体外循环冠脉旁路移植术中的应用评价[J]. 包头医学院学报,2011, 27(1):46-48.
[6] BISCHOF D B,GANTER M T,SHORE-LESSERSON L, et al.Viscoelastic blood coagulation measurement with Sonoclot predicts postoperative bleeding in cardiac surgery after heparin reversal[J]. J Cardiothorac Vasc Anesth,2015, 29(3):715-722.
[7] YAMADA T,KATORI N,TANAKA K A,et al.Impact of Sonoclot hemostasis analysis after cardiopulmonary bypass on postoperative hemorrhage in cardiac surgery[J]. J Anesth,2007,21(2):148-152.
[8] SAITO H,KAWANA S,SAITO K,et al.Sonoclot® predicts operation time and blood loss after cardiopulmonary bypass in children[J]. Heliyon,2022,8(11):e11461.
[9] CHAUDHARY V,CHAUHAN S,CHOUDHURY M,et al.Sonoclot analysis in children with congenital heart disease[J]. Asian Cardiovasc Thorac Ann,2012,20(5):544-547.
[10] BHARDWAJ V,MALHOTRA P,HASIJA S,et al.Coagulopathies in cyanotic cardiac patients: An analysis with three point-of-care testing devices (Thromboelastography, rotational thromboelastometry,and sonoclot analyzer)[J]. Ann Card Anaesth,2017,20(2):212-218.
[11] VANDENHEUVEL M,VAN GOMPEL C,VANDEWIELE K,et al.Comparison of coagulation monitoring using ROTEM and Sonoclot devices in cardiac surgery: a single-center prospective observational study[J]. Minerva Anestesiol,2022,88(9):680-689.
[12] KUMAR A,JOSHI S,GHUMMAN B P S,et al. Comparison of the predictive value of thromboelastography and Sonoclot analysis for postoperative bleeding in children undergoing corrective surgery for cyanotic congenital heart disease[J]. Med J Armed Forces India, 2022,78(4):413-421.
[13] RAJKUMAR V,KUMAR B,DUTTA V,et al.Utility of sonoclot in prediction of postoperative bleeding in pediatric patients undergoing cardiac surgery for congenital cyanotic heart disease: a prospective observational study[J]. J Cardiothorac Vasc Anesth,2017,31(3):901-908.
[14] TERADA R,IKEDA T,MORI Y,et al.Comparison of two point of care whole blood coagulation analysis devices and conventional coagulation tests as a predicting tool of perioperative bleeding in adult cardiac surgery—a pilot prospective observational study in Japan[J]. Transfusion, 2019,59(11):3525-3535.
[15] SATO T,EDANAGA M,YAMAKAGE M,et al.Platelet function testing using sonoclot and TEG6s as a platelet transfusion prediction tool in open heart surgery[J]. Cureus, 2023,15(11):e49131.
[16] ICHIKAWA Y,KAWANO K,MORI M,et al.Sonoclot's usefulness in prediction of cardiopulmonary arrest prognosis: A proof of concept study[J]. Open Med,2022, 17(1):414-422.
[17] AGGARWAL V,KAPOOR P M,CHOUDHURY M,et al.Utility of Sonoclot analysis and tranexamic acid in tetralogy of Fallot patients undergoing intracardiac repair[J]. Ann Card Anaesth,2012,15(1):26-31.
[18] SIEDERS E,DE SOMER F,BOUCHEZ S,et al.Haemostasis monitoring during sequential aortic valve replacement and liver transplantation[J]. Acta Gastroenterol Belg,2010,73(1):65-68.
[19] SAXENA P,BIHARI C,RASTOGI A,et al.Sonoclot signature analysis in patients with liver disease and its correlation with conventional coagulation studies[J]. Adv Hematol,2013,2013:237351.
[20] PREMKUMAR M,MEHTANI R,DIVYAVEER S,et al.Clinical validation of global coagulation tests to guide blood component transfusions in cirrhosis and ACLF[J]. J Clin Transl Hepatol,2021,9(2):210-219.
[21] PREMKUMAR M,MEHTANI R,KULKARNI A V,et al.Association of heparin-like effect,factor Ⅶ/ⅫⅠ deficiency and fibrinolysis with rebleeding risk in cirrhosis with acute variceal bleeding[J]. Dig Dis Sci,2023,68(2):497-513.
[22] SLOFSTRA S H,ARNOLD SPEK C,TEN CATE H.Disseminated intravascular coagulation[J]. Hematol J, 2003,4(5):295-302.
[23] WAN P,TONG H S,ZHANG X Q,et al.Diagnosis of overt disseminated intravascular coagulation in critically Ill adults by Sonoclot coagulation analysis[J]. Int J Hematol,2014,100(2):125-131.
[24] WAN P,YU M,QIAN M,et al.Sonoclot coagulation analysis: a useful tool to predict mortality in overt disseminated intravascular coagulation[J]. Blood Coagul Fibrinolysis,2016,27(1):77-83.
[25] WAN P,GENG Y,SU L,et al.Managing coagulation using the sonoclot analyzer in patients with disseminated intravascular coagulation[J]. Am J Crit Care,2025,34(3): 194-207.
[26] SCHLEGEL R N,FITZGERALD M,LIM A,et al.Injury patterns,management and outcomes of retroperitoneal haemorrhage caused by lower intercostal arterial bleeding at a level-1 trauma centre: A 10-year retrospective review[J]. Emerg Med Australas,2023,35(1):56-61.
[27] 代铮,刘善收,张琪,等. 新型凝血检测技术在评估创伤失血性休克合并凝血功能障碍患者早期病情中的应用[J]. 临床误诊误治,2025,38(3):33-39.
[28] SINGER M,DEUTSCHMAN C S,SEYMOUR C W,et al.The third international consensus definitions for sepsis and septic shock (sepsis-3)[J]. JAMA,2016,315(8):801-810.
[29] 王莉,吴海鹰,张玮,等. 脓毒症患者SONOCLOT凝血功能变化特点分析[J]. 临床合理用药杂志,2017,10(1):58-60.
[30] 孙鸿鹏,张谦,周厚荣,等. 脓毒症并ARDS患者Sonoclot凝血功能检测的研究[J]. 贵州医药,2016,40(1):19-21.
[31] 王海曼,刘景峰,段美丽. Sonoclot凝血功能分析仪在脓毒症DIC患者中的应用[J]. 临床和实验医学杂志,2015, 14(23):1966-1969.
[32] DIVYAVEER S,CHAHAL S,KASHYAP M,et al.Comparison of standard and global coagulation tests in hemodialysis patients[J]. Indian J Nephrol,2025,35(2): 259-264.
[33] 王吉苹,郭傲,石宏宇,等. Sonoclot凝血分析仪在产科子痫前期的应用[J]. 长春中医药大学学报,2022,38(12):1389-1391.
[34] SHI H Y,WANG W J,LI F,et al.Model construction and application for predicting pre-eclampsia by Sonoclot coagulation analyzer[J]. Noncoding RNA Res,2024,9(2): 288-293.
[35] MISHRA K,JANDIAL A,SANDAL R,et al.Bleeding risk assessment in immune thrombocytopenia[J]. Ann Hematol,2023,102(11):3007-3014.
[36] 冯立云,张谦,吴明,等. Sonoclot监测ARDS患者凝血功能与PMA的表达的相关性研究[J]. 贵州医药,2017, 41(6):581-583.
[37] LUDHIADCH A,YADAV P,SINGH S K,et al.Evaluation of mean platelet volume and platelet count in ischemic stroke and its subtypes: focus on degree of disability and thrombus formation[J]. Int J Neurosci,2024,134(5): 503-510.
[38] MIN J Y,WAN P,LIU G W,et al.Sonoclot signature analysis: a new point-of-care testing method for defining heat stroke-induced coagulopathy[J]. Int J Gen Med,2021,14:6925-6933.
[39] LEE B,AL-WAILI N,BUTLER G,et al.Assessment of heparin anticoagulation by Sonoclot Analyzer in arterial reconstruction surgery[J]. Technol Health Care,2011, 19(2):109-114.
[40] LI S W,FENG X,XU H,et al.Comparison on anticoagulation and antiplatelet aggregation effects of puerarin with heparin sodium and tirofiban hydrochloride: an in vitro study[J]. Chin J Integr Med,2018,24(2):103-108.
[41] WANG J Q,SHI X B,YANG J G,et al.In vitro anticoagulation monitoring of low-molecular-weight heparin[J]. Chin Med J,2009,122(10):1199-1202.
[42] SCHÖTT U,NILSSON L G,BROMAN M,et al. Monitoring of low molecular weight heparin anticoagulation during haemodialysis with a Sonoclot Analyzer[J]. Perfusion,2010,25(4):191-196.
[43] 何昕昕,丰艳,郭剑颖. 低分子肝素对下肢骨折高龄患者凝血功能的影响及Sonoclot凝血及血小板功能分析仪监测效果评估[J]. 临床与病理杂志,2021,41(12):2894-2899.
[44] PENG P G,CHEN Y W,YANG G,et al.Glass bead-activated clotting time (gb-ACT) for monitoring the anticoagulation effects in elderly patients with high risk of venous thromboembolism (VTE)[J]. Expert Opin Drug Saf,2024,23(7):869-876.
[45] HASIJA S,KAPOOR P M.Effect of heparin and Bivalirudin on the kinetics of clot formation: Viscoelastic coagulation testing[J]. Ann Card Anaesth,2017,20(1): 122.
[46] YANG W X,LAI C L,CHEN F H,et al.The value of Sonoclot detection technology to guide the clinical medication of the perioperative anticoagulation and antiplatelet therapy in patients with acute myocardial infarction undergoing emergent PCI[J]. Exp Ther Med,2017,13(6):2917-2921.
[47] KANDER T,DANKIEWICZ J,FRIBERG H,et al.Platelet aggregation and clot formation in comatose survivors of cardiac arrest treated with induced hypothermia and dual platelet inhibition with aspirin and ticagrelor;a prospective observational study[J]. Crit Care,2014, 18(5):495.
[48] 卢洁,张梅,姜铁民,等. Sonoclot监测冠心病患者服用双联抗血小板药物后凝血及血小板功能[J]. 临床荟萃, 2012,27(8):681-684.
[49] BRANDY K R,MEYER R M,LUO X H,et al.Evaluation of the coagulation profile among oral and vaginal combined hormonal contraceptive users using sonoclot coagulation analyzer[J]. Clin Appl Thromb Hemost,2012,18(6):576-581.
[50] YANG W J,GOU H L,LI H,et al.Intravenous tranexamic acid improves the intraoperative visualization of endoscopic sinus surgery for high-grade chronic rhinosinusitis: a randomized,controlled,double-blinded prospective trial[J]. Front Surg,2021,8:771159.
[51] TANTRY T P,HANDE M,RAO P K,et al.Intraoperative Sonoclot analysis in oncosurgical massive hemorrhage: A case series of coagulation curve abnormalities[J]. Saudi J Anaesth,2025,19(3):432-436.

Research Progress on the Clinical Application of Sonoclot Coagulation and Platelet Function Analysis

RichHTML

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

About

Author

Journal

Access Statistics

Contact

[1]	XIA Yuexin, YANG Yicheng, LI Chunxiang, ZHOU Shihang, LIU zhiyuan. Analysis of Mixed Vision in 17 Cases of ABO Blood Group Typing and Identification of Their Alleles Using PacBio SMRT Third-generation Sequencing Technology [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(3): 306-309.
[2]	LIAO Yuanmeng, HE Yuan. Blood Agglutination Phenomenon in COVID-19 Infection [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(3): 423-426.
[3]	GAO Chengyan, GONG Guoqin, CAI Xiaohong, XIANG Dong. Comparative Analysis of the Saline Medium Tube Method and Column Agglutination Method in the Detection of Unexpected Red Blood Cell Antibodies [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(2): 175-178.
[4]	TIAN Wen, XU Ning, WU Tiange, SHI Minghao, LI Yao, PEI Xiaoxian, YU Na. Serological and Gene Sequence Analysis of Weakened A Antigen in Four Cases [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(2): 186-190.
[5]	HUANG Yaojing, CHEN Zhengkang, LU Aihong, LU Baiye, ZHU Yikuan, HUANG Junli, YE Lan, ZHOU Yufei. Levels of Serum Uric Acid and Lipid in First-time Plasma Donors in Guangdong and Guangxi [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(4): 521-530.
[6]	HE Zhi-chun, XU Bei, QIU Ying-jie, et al. Influence of Blood Donors'sex and Age on Hemolysis Rate of Red Cells in Additive Solution during the Late Storage Period [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(6): 763-766.
[7]	SONG Ying-wei, BIAN Cheng-rong, PAN Xue, et al. The Effect of Multiple Platelet Donation on some Parameters of the Blood Routine in Male Apheresis Platelet Donors [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(5): 610-614.
[8]	CHEN Jing, TONG Xin-yuan. Correlation Study between Coagulation Factor, Anticoagulant Protein, PLG and vWF, Traditional Coagulation Test and Common TEG Parameters [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2021, 23(3): 345-349.
[9]	. [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2021, 23(3): 400-404.
[10]	SHEN Wei-wei, LI Zong-feng, PU Qiu-ning, et al. Changes and Significance of Serum Bilirubin Level in Patients with Lupus Nephritis [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2020, 22(5): 533-537.
[11]	CHEN Jiang, XIANG Hong-zhou, LI Zheng, et al. Value of STAT3 in Diagnosis and Prognosis of Pancreatic Cancer [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2020, 22(2): 156-160.
[12]	WEI Xiao-zhu, SU Wei, CHEN Wang, et al. The Correlation between The Prevalence of Hyperuricemia and The Polymorphisms of SLC2A9 Gene Rs2241480 in Coastal Population [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2020, 22(2): 160-164.
[13]	ZHU Jia-ping, YAN Neng-bin. Association of Macro- and Trace-Elements with Depression：A Case-Control Study [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2020, 22(2): 164-168.
[14]	HE Jing-yuan. A Correlative Study of Total Bile Acid in the Mothers with Intrahepatic Cholestasis and Perinatal Infants [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2020, 22(2): 181-184.
[15]	SU Wei, WEI Xiao-zhu, LIU Ai-ling.et al. Sigma Performance Verification Diagram for Evaluation of Biochemical Analyzers [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2020, 22(2): 195-199.