Research Progress of Platelet-rich Plasma Combined with Mesenchymal Stem Cell Therapy in Tissue Regeneration

doi:10.3969/j.issn.1671-2587.2025.05.022

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (5): 736-743.DOI: 10.3969/j.issn.1671-2587.2025.05.022

Research Progress of Platelet-rich Plasma Combined with Mesenchymal Stem Cell Therapy in Tissue Regeneration

GONG Jin¹, WANG Haiying², CHEN Lili², WANG Hui¹, ZHANG Jinjin^1,2, XING Yanchao^1,2

¹School of Postgraduates, Xinjiang Medical University, Urumqi 830054;
²Department of Blood Transfusion, General Hospital of Xinjiang Military Command, Urumqi 830099

Received:2025-09-01 Revised:2025-09-11 Online:2025-10-20 Published:2025-10-11

Abstract

Abstract: Tissue regeneration is a central objective in the field of regenerative medicine and is currently confronted with pivotal bottlenecks such as low survival of transplanted cells, limited functionality, and an imbalanced microenvironment. The combination of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) offers a new strategy to address these challenges through multi-pathway synergism that optimizes the microenvironment. The growth factors abundant in PRP can significantly enhance MSC survival and function, exhibiting synergistic effects in the repair of various tissue injuries. This article systematically elaborates on the molecular mechanisms by which PRP regulates MSC function, the research progress of the combined therapy in animal models, and the current status of clinical application, with the aim of providing novel theoretical foundations and practical directions for tissue-regenerative treatment.

Key words: Tissue regeneration, Mesenchymal Stem Cells, Platelet-rich plasma, Synergistic effect

CLC Number:

R457

GONG Jin, WANG Haiying, CHEN Lili, WANG Hui, ZHANG Jinjin, XING Yanchao. Research Progress of Platelet-rich Plasma Combined with Mesenchymal Stem Cell Therapy in Tissue Regeneration[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(5): 736-743.

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Research Progress of Platelet-rich Plasma Combined with Mesenchymal Stem Cell Therapy in Tissue Regeneration

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