Abstract: Objective To assess the efficacy of autologous platelet-rich plasma （aPRP） treatment in children with pathologic fractures. Methods Eleven children in Wuhan Children's Hospital who were diagnosed with pathologic fractures and required orthopedic surgery based on clinical data and imaging examination,were enrolled. Children treated with aPRP prepared by manual preparation method were selected as the treatment group,while those not treated with aPRP were selected as the control group. The postoperative fracture healing was observed and patient satisfaction was carried. Results No adverse reactions occurred in the 4 children treated with PRP, and the fracture healing cycle was shorter than that in the control group（χ²=4.860,P=0.027）. The satisfaction of the children and their families was higher（χ²=4.860,P=0.027）. Conclusion Platelet-rich plasma enhance pathologic fracture healing in children and shorten treatment time. It improves patient satisfaction.

Key words: Autologous platelet-rich plasma, Pathological fractures, Children