Abstract: Objective To analyze the related factors of adverse reactions of blood transfusion so as to provide evidence for clinical prevention and reduction of the side effect of transfusion in children. Methods Data were collected and analyzed in pediatric blood transfusions from 2009 to 2014. Results A total of 30 518 transfusions were performed during six consecutive years in the children's hospital，among them 166 transfusion reactions were recorded，the incidence was 0.54% and the frequency of allergic reaction was 80.73%（134/166）. The most common reactions included fever （12.65%，21/166）and platelets-associated disorders（1.92%，P<0.05）.Incidence of reactions in children was not related to gender. Patients over one year of age had a higher occurrence rate of reactions following transfusion than those aged 0-1 year （P<0.05）. The incidence was significantly higher in children with more than 3 times of transfusion than others （P<0.05）. Children with leukemia，renal or rheumatic disorders were susceptible to adverse reactions（P＜0.05）. Conclusions Junior patients present a higher incidence of adverse effect after transfusion and thus unnecessary transfusion should be avoided. Children with leukemia，kidney disease or rheumatism，particularly with the age over one year and with the history of 3 times of transfusion，should be strictly monitored for the risk of transfusion reactions.

Key words: Children , Adverse reaction of blood transfusion , Allergic reaction, History of blood transfusion, Apheresis platelets