Study of Thromboelastography in 110 Children with Kawasaki Disease

doi:10.3969/j.issn.1671-2587.2021.01.018

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2021, Vol. 23 ›› Issue (1): 71-74.DOI: 10.3969/j.issn.1671-2587.2021.01.018

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Study of Thromboelastography in 110 Children with Kawasaki Disease

QIU Li-juan, FU Xiao-yan, MA Shu-xuan, et al

Department of Transfusion Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Childrens' Health, Beijing 100045

Received:2019-09-26 Published:2021-02-22

Abstract

Abstract: Objective To analyze the characteristics of thromboelastography in children with Kawasaki disease （KD）and provide laboratory evidence for its diagnosis and treatment. Methods A total of 110 children's KD cases in Beijing Children's Hospital from January 1,2016 to September 30,2016 were enrolled as the experimental group,and 60 children undergoing selective operation with normal coagulation function were recruited as the control group. The baseline results of TEG, blood coagulation and platelet count were retrospectively analyzed. TEG parameters include reaction time（R value）,clotting time（K value）,α angle,maximum amplitude（MA value）,estimated percentage of dissolution（EPL）,percentage of dissolution 30 minutes after MA（LY30）and comprehensive coagulation index（CI）. Results The levels of R and K value in the experimental group were significantly lower than those in control group（P<0.01）,and the levels of αangle,MA,EPL,LY30 and CI in the experimental group were significantly higher than those in the control group（P<0.01）. Conclusion Children with KD had increased coagulation factor activity,high fibrinogen content,high platelet number or hyperfunction,and fibrinolytic system was out of balance,which showing a hypercoagulable state overall.

Key words: Kawasaki disease, Children, Thromboelastography

CLC Number:

R725.4R446.11

QIU Li-juan, FU Xiao-yan, MA Shu-xuan, et al. Study of Thromboelastography in 110 Children with Kawasaki Disease[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2021, 23(1): 71-74.

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Study of Thromboelastography in 110 Children with Kawasaki Disease

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