Abstract: Objective To explore the safe blood transfusion strategy for thalassemia in children in Yunnan Province. Methods A total of 2 620 children diagnosed with thalassemia who received once or repeated blood transfusions in eight cities with a high incidence of thalassemia in Yunnan Province before（from 2012 to 2016）and after （from 2017 to 2021） the implementation of the safe blood transfusion strategy were selected. The positive rate of screening antibodies and the incidence of adverse reactions in blood transfusion were compared. Results After the implementation of the strategy,the positive rate of screening antibodies and the incidence of adverse reactions in blood transfusion were significantly reduced. The positive rate of screening antibodies decreased from 33.62% to 7.64%,and the incidence of adverse reactions in blood transfusion decreased from 4.31% to 0.36%,and the differences were statistically significant（P<0.01）. Conclusion The safe transfusion strategy is scientific,reasonable and effective. The detection of ABO,Rh-CcDEe and MNSs blood group antigen and screening antibodies should be performed in practice in children with thalassemia. Prophylactic ABO,Rh-CcDEe and MNSs antigen-matched blood is transfused to ensure the safety and effectiveness of transfusion therapy.

Key words: Yunnan, Thalassemia children, Transfusion therapy, Transfusion safety strategy