Advances in the Study on the Molecular Mechanisms of Ginkgolide B in Regulating Platelet Activation

doi:10.3969/j.issn.1671-2587.2026.01.023

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2026, Vol. 28 ›› Issue (1): 146-152.DOI: 10.3969/j.issn.1671-2587.2026.01.023

Advances in the Study on the Molecular Mechanisms of Ginkgolide B in Regulating Platelet Activation

HE Ying, FENG Wenqiu, QIN Ping, ZHU Peiyuan

Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210022

Received:2025-07-14 Published:2026-02-13

Abstract

Abstract: Ginkgolide B is a typical diterpene lactone active ingredient extracted from the traditional Chinese medicine Ginkgo biloba, which has the effect of efficiently antagonizing platelet-activating factor, and can be involved in the inhibition of platelet activation, antioxidant, anti-thrombosis, and protection of blood vessels, especially in the regulation of platelet function demonstrates a good prospect of application. Mechanistically, GB can exert its effects through multiple signaling pathways, including Ca²⁺ signaling pathway, phosphatidylinositol 3-kinase signaling axis, arachidonic acid metabolic pathway and integrin αⅡbβ3-mediated signaling pathway, so as to exert the effect of platelet function regulation.

Key words: Ginkgolide B, Platelet function, Signaling pathway, platelet activation

CLC Number:

R285.5R446.1

HE Ying, FENG Wenqiu, QIN Ping, ZHU Peiyuan. Advances in the Study on the Molecular Mechanisms of Ginkgolide B in Regulating Platelet Activation[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2026, 28(1): 146-152.

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Advances in the Study on the Molecular Mechanisms of Ginkgolide B in Regulating Platelet Activation

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