Dengue Fever and Blood Transfusion Safety

doi:10.3969/j.issn.1671-2587.2025.03.023

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (3): 427-432.DOI: 10.3969/j.issn.1671-2587.2025.03.023

Dengue Fever and Blood Transfusion Safety

WANG Yilai, HE Ziyi

Dongguan Blood Center, Dongguan 523000

Received:2024-11-29 Published:2025-06-23

Abstract

Abstract: Dengue fever caused by mosquito-borne viruses is spreading rapidly around the world, mainly in tropical, subtropical countries. In recent years, dengue fever has expanded epidemic trend in our country, now there are also studies showing that dengue fever can be transmitted through blood transfusion, which not only poses a serious threat to public health, but also poses a potential risk to the safety of blood transfusion. This article reviews the biological characteristics, epidemiology, transmission routes, clinical symptoms, detection methods, blood transfusion safety status, blood transfusion prevention, control strategies of dengue fever.

Key words: Dengue fever, Dengue virus, Blood transfusion safety, Mosquito-borne transmission

CLC Number:

R512.8R457.1

WANG Yilai, HE Ziyi. Dengue Fever and Blood Transfusion Safety[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(3): 427-432.

References

[1] BIFANI A M,SIRIPHANITCHAKORN T,CHOY M M.Intra-host diversity of dengue virus in mosquito vectors[J]. Front Cell Infect Microbiol,2022,12:888804.
[2] POSTLER T S,BEER M,BLITVICH B J,et al.Renaming of the genus Flavivirus to Orthoflavivirus and extension of binomial species names within the family Flaviviridae[J]. Arch Virol,2023,168(9):224.
[3] ZHAO Z,YUE Y J,LIU X B,et al.The patterns and driving forces of dengue invasions in China[J]. Infect Dis Poverty,2023,12(1):42.
[4] KOK B H,LIM H T,LIM C P,et al.Dengue virus infection-a review of pathogenesis,vaccines,diagnosis and therapy[J]. Virus Res,2023,324:199018.
[5] CHEN S,WU Z,WANG M S,et al.Innate immune evasion mediated by Flaviviridae non-structural proteins[J]. Viruses,2017,9(10):291.
[6] MA M M,WU S A,HE Z J,et al.New genotype invasion of dengue virus serotype 1 drove massive outbreak in Guangzhou,China[J]. Parasit Vectors,2021,14(1):126.
[7] 张复春,何剑峰,彭劼,等. 中国登革热临床诊断和治疗指南[J]. 中华内科杂志,2018,57(9): 642-648.
[8] WHO. Dengue and severe dengue[EB/OL]. (2024-04-23)https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue.
[9] KHAN S,AKBAR S M F,YAHIRO T,et al. Dengue infections during COVID-19 period:reflection of reality or elusive data due to effect of pandemic[J]. Int J Environ Res Public Health,2022,19(17):10768.
[10] KHAN M B,YANG Z S,LIN C Y,et al.Dengue overview:an updated systemic review[J]. J Infect Public Health,2023,16(10):1625-1642.
[11] XU C D,XU J Y,WANG L.Long-term effects of climate factors on dengue fever over a 40-year period[J]. BMC Public Health,2024,24(1):1451.
[12] KHAN M,PEDERSEN M,ZHU M,et al.Dengue transmission under future climate and human population changes in mainland China[J]. Appl Math Model, 2023,114:785-798.
[13] 熊益权,陈清.1978~2014年我国登革热的流行病学分析[J].南方医科大学学报,2014,34(12):1822-1825.
[14] WU T T,WU Z D,LI Y P.Dengue fever and dengue virus in the people's republic of China[J]. Rev Med Virol, 2022,32(1):e2245.
[15] 岳玉娟,刘小波,郭玉红,等. 2020—2022年中国登革热时空分布及相关环境因素分析[J]. 环境卫生学杂志, 2023,13(5):341-345.
[16] 岳玉娟,刘小波,任东升,等. 中国大陆2005—2020年登革热流行病学特征分析[J]. 中国媒介生物学及控制杂志, 2023,34(6):761-766.
[17] YUE Y J,LIU Q Y,LIU X B,et al.Dengue fever in mainland China,2005—2020:a descriptive analysis of dengue cases and Aedes data[J]. Int J Environ Res Public Health,2022,19(7):3910.
[18] 高娜,盛子洋. 登革热疾病负担及预防控制策略中国专家共识[J]. 中国人兽共患病学报,2024,40(6):489-497.
[19] BREM J,ELANKESWARAN B,ERNE D,et al.Dengue “homegrown” in Europe (2022 to 2023)[J]. New Microbes New Infect,2023,56:101205.
[20] 林健燕,郭泽强,邱昌文. 非蚊媒途径传播登革病毒的研究进展[J]. 中国热带医学,2018,18(4):406-409.
[21] ZAMBRANO L E A,ZEVALLOS V M V,SORAYA G V, et al. Transplacental transmission of dengue infection[J]. World J Virol,2024,13(3):91325.
[22] 林健燕,郭泽强,邱昌文,等. 登革热的流行形势及其对血液安全性的影响[J]. 广西医学,2017,39(4):517-518.
[23] CÁCERES MUNAR B A,URBINA A,ORTÍZ T,et al. High prevalence of dengue,Zika,and chikungunya viruses in blood donors during a dengue outbreak and an endemic period in Colombia[J]. Front Med (Lausanne), 2024,11:1380129.
[24] CUI F F,HE F W,HUANG X R,et al.Dengue and dengue virus in Guangdong,China,1978-2017:epidemiology,seroprevalence,evolution,and policies[J]. Front Med (Lausanne),2022,9:797674.
[25] 林芬,杨辉,杨立业,等. 528例登革热患者临床表现与实验室数据的回顾性分析[J]. 检验医学与临床, 2017,14(12): 1726-1728.
[26] Thomas S J, Rothman A L, Srikiatkhachorn A, et al.Dengue virus infection: clinical manifestations and diagnosis[J]. Waltham, MA, USA: UpToDate, 2018.
[27] 中华医学会感染病学分会,中华医学会热带病与寄生虫学分会,中华中医药学会急诊分会.中国登革热临床诊断和治疗指南[J]. 传染病信息,2018,31(5):385-392.
[28] 刘铁柱,李建东. 登革热病原学与实验室检测技术研究进展[J]. 病毒学报,2024,40(3):588-597.
[29] 严延生,翁育伟. 寨卡病毒与登革热病毒交叉反应抗体引发严重性疾病的关系[J]. 中国人兽共患病学报,2017, 33(2):93-97.
[30] BHATT P,SABEENA S P,VARMA M,et al.Current understanding of the pathogenesis of dengue virus infection[J]. Curr Microbiol,2021,78(1):17-32.
[31] 秦圆方,张欣,张复春,等. 登革热抗原抗体联合检测与双抗体检测效能比较[J]. 江苏预防医学,2023,34(6):770-772.
[32] IQBAL G,JAVED H,RAZA F A,et al.Diagnosis of acute dengue virus infection using enzyme-linked immunosorbent assay and real-time PCR[J]. Can J Infect Dis Med Microbiol,2023,2023:3995366.
[33] POLLAK N M,OLSSON M,AHMED M,et al.Rapid diagnostic tests for the detection of the four dengue virus serotypes in clinically relevant matrices[J]. Microbiol Spectr,2023,11(1):e0279622.
[34] POZZETTO B,MEMMI M,GARRAUD O.Is transfusion-transmitted dengue fever a potential public health threat?[J]. World J Virol,2015,4(2):113-123.
[35] CHUANG V W, WONG T Y, LEUNG Y H, et al.Review of dengue fever cases in Hong Kong during 1998 to 2005[J]. Hong Kong Medical Journal,2008,14(3):170.
[36] TAMBYAH P A,KOAY E S C,POON M L M,et al. Dengue hemorrhagic fever transmitted by blood transfusion[J]. N Engl J Med,2008,359(14):1526-1527.
[37] LEVI J E,NISHIYA A,FÉLIX A C,et al. Real-time symptomatic case of transfusion-transmitted dengue[J]. Transfusion,2015,55(5):961-964.
[38] ALMEIDA F J,PACHECO J T,FARIAS C G A,et al. Dengue:a hidden threat in blood transfusions amidst Brazil's largest outbreak?[J]. Lancet Infect Dis,2025, 25(1):e10.
[39] KARIM F,NASIR N,MOIZ B.Transfusion transmitted dengue:One donor infects two patients[J]. Transfus Apher Sci,2017,56(2):151-153.
[40] STRAMER S L,LINNEN J M,CARRICK J M,et al.Dengue viremia in blood donors identified by RNA and detection of dengue transfusion transmission during the 2007 dengue outbreak in Puerto Rico[J]. Transfusion, 2012,52(8):1657-1666.
[41] PERERA L,DE ZOYSA N,JAYARAJAH U,et al.Transfusion-transmissible dengue infections[J]. Trans R Soc Trop Med Hyg,2020,114(11):866-882.
[42] GIMÉNEZ-RICHARTE Á,ORTIZ DE SALAZAR M I,GIMÉNEZ-RICHARTE M P,et al. Transfusion-transmitted arboviruses:Update and systematic review[J].PLoS Negl Trop Dis,2022,16(10):e0010843.
[43] KAUR P,KAUR G.Transfusion support in patients with dengue fever[J]. Int J Appl Basic Med Res,2014, 4(Suppl 1):S8-S12.
[44] GOH Z J,LI R Q,WANG M X,et al. Transfusion of blood products and clinical outcomes for patients with dengue fever:a systematic review and meta-analysis[J]. Open Forum Infect Dis,2024,11(9):ofae507.
[45] YAN G,TAMBYAH P.Transfusion-transmitted infections:lessons from dengue in Taiwan[J]. J Infect Dis,2022,225(9):1497-1499.
[46] CHEN Y Y,LU C T,TSAI M H,et al.Dengue virus ribonucleic acid detection rates in blood donors correlate with local infection incidences during a dengue outbreak in Taiwan[J]. J Infect Dis,2022,225(9):1504-1512.
[47] LI L,LI Y,LU S F,et al.Epidemiological survey and screening strategy for dengue virus in blood donors from Yunnan Province[J]. BMC Infect Dis,2021,21(1):104.
[48] 林健燕,广西献血员登革热流行情况及其对血液安全的影响[R].广西壮族自治区,南宁输血医学研究所,2019-03-26.
[49] 李军伟,李小伟,陈丹. 血清型登革热病毒PCR方法学评估与应用[J]. 河南预防医学杂志,2017,28(10):726-729.
[50] KATZELNICK L C,COELLO ESCOTO A,HUANG A T,et al.Antigenic evolution of dengue viruses over 20 years[J]. Science,2021,374(6570):999-1004.
[51] ST JOHN A L,RATHORE A P S. Adaptive immune responses to primary and secondary dengue virus infections[J]. Nat Rev Immunol,2019,19(4):218-230.
[52] 郭泽强,林健燕,罗必泰,等. 南宁市登革热大流行后人群中抗原抗体的变化[J]. 中国热带医学,2019,19(4):348-351.
[53] BUSCH M P,SABINO E C,BRAMBILLA D,et al.Duration of dengue viremia in blood donors and relationships between donor viremia,infection incidence and clinical case reports during a large epidemic[J]. J Infect Dis,2016,214(1):49-54.
[54] PETERSEN L R,TOMASHEK K M,BIGGERSTAFF B J.Estimated prevalence of dengue viremia in Puerto Rican blood donations,1995 through 2010[J]. Transfusion, 2012,52(8):1647-1651.
[55] KULKARNI R,TIRAKI D,WANI D,et al.Risk of transfusion-associated dengue:screening of blood donors from Pune,western India[J]. Transfusion,2019, 59(2):458-462.
[56] GIMÉNEZ-RICHARTE Á,ORTIZ DE SALAZAR M I,GIMÉNEZ-RICHARTE M P,et al. Pathogen inactivation methods to prevent transfusion-transmissible arboviruses: a systematic review and meta-analysis[J]. Trop Med Int Health,2023,28(4):262-274.
[57] 康澜,李世林,杨春晖.血液成分中病原体灭活技术及其研究进展[J]. 临床输血与检验,2022,24(4):521-527.
[58] 李玉佳,段晓琼,王艳翠,等. 四种病毒灭活方法用于登革病毒灭活效果的比较[J]. 中国输血杂志,2020,33(2):109-113.
[59] STRAMER S L,LANTERI M C,BRODSKY J P,et al.Mitigating the risk of transfusion-transmitted infections with vector-borne agents solely by means of pathogen reduction[J]. Transfusion,2022,62(7):1388-1398.
[60] 王义来,陈庆恺,韩国伟,等. 寨卡病毒与血液安全[J]. 临床输血与检验,2024,26(6):859-864.

Dengue Fever and Blood Transfusion Safety

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