Advances in the Mechanism of Fatty Acid Synthase in Autoimmune Diseases

doi:10.3969/j.issn.1671-2587.2025.04.019

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (4): 557-563.DOI: 10.3969/j.issn.1671-2587.2025.04.019

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Advances in the Mechanism of Fatty Acid Synthase in Autoimmune Diseases

ZHAO Xianxian¹, SUN Maoyun¹, LI Dandan², WANG Zhicheng²

¹Jining No.1 People's Hospital, Jining 272000;
²Huashan Hospital Affiliated to FudanUniversity, Shanghai 200040

Received:2025-05-28 Published:2025-08-22

Abstract

Abstract: Fatty acid synthase (FASN) is a key enzyme that catalyzes the de novo synthesis of fatty acids, with its classical functions primarily associated with energy storage and biofilm construction. Accumulating evidence indicates that FASN contributes to the occurrence and development of autoimmune diseases through the regulation of cellular signal transduction, modulation of inflammatory responses, and influence on immune cell function. This review summarizes the structural characteristics of FASN, its regulatory roles in immune cell activity, its underlying mechanisms in autoimmune pathogenesis, and explores potential therapeutic strategies targeting FASN, with the aim of providing novel insights into the treatment of autoimmune disorders.

Key words: Fatty acid synthase, Immune cell function, Autoimmune diseases

CLC Number:

R593.2

ZHAO Xianxian, SUN Maoyun, LI Dandan, WANG Zhicheng. Advances in the Mechanism of Fatty Acid Synthase in Autoimmune Diseases[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(4): 557-563.

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Advances in the Mechanism of Fatty Acid Synthase in Autoimmune Diseases

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