Sex-specific Variations in the Autoantibody Profiles of Intravenous Human Immunoglobulins Derived from Plasma Donations

doi:10.3969/j.issn.1671-2587.2025.01.013

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2025, Vol. 27 ›› Issue (1): 89-100.DOI: 10.3969/j.issn.1671-2587.2025.01.013

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Sex-specific Variations in the Autoantibody Profiles of Intravenous Human Immunoglobulins Derived from Plasma Donations

ZHANG Wei¹, HUANG Yaojing², MA Li¹, ZHANG Yunjia³, Hou Mingxia³, ZHANG Zhan³, WANG Zongkui¹, LI Changqing¹

¹Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, Chengdu 610052;
²Bama Plasmapheresis Center, Hechi 547500; 3Shenzhen Weiguang Biological Products Co., Ltd., Shenzhen 518107

Received:2024-07-16 Published:2025-02-25

Abstract

Abstract: Objective To investigate the differences in autoantibody profiles of intravenous immunoglobulin (IVIG) derived from distinct sex-specific plasma (DSP-IVIG). Methods To achieve this objective, we used the HuProt^TM20K arrays, a comprehensive platform for autoantibody detection, to analyze the autoantibody profiles of DSP-IVIG. Then, we did a bioinformatics analysis to characterize the differentially expressed autoantibody proteins. Results There were significant differences in the autoantibody profiles between DSP-IVIG samples. These differences mainly involved the immune regulatory network encompassing critical processes such as T cell line differentiation, IL-17 signaling pathway modulation, and the interplay of cytokines and chemokines. Conclusion Notable sex-specific variations exist in the autoantibody profiles of IVIG derived from plasma of different sexes.

Key words: Intravenous Immunoglobulin, IVIG derived from distinct sex-specific plasma, Autoantibody profiles, Autoimmune diseases

CLC Number:

R457

ZHANG Wei, HUANG Yaojing, MA Li, ZHANG Yunjia, Hou Mingxia, ZHANG Zhan, WANG Zongkui, LI Changqing. Sex-specific Variations in the Autoantibody Profiles of Intravenous Human Immunoglobulins Derived from Plasma Donations[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(1): 89-100.

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Sex-specific Variations in the Autoantibody Profiles of Intravenous Human Immunoglobulins Derived from Plasma Donations

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