Abstract: Objective To report one case of hemolytic anemiainducedby cefoperazone-sulbactam sodium, with theestablishment of diagnostic procedure for the patient. Methods The anti-human globulin test and DAT typing of erythrocytes were performed in the patient. The antibodies against the drugs weredetected by drug-sensitized erythrocytes and the hemolytic and coagulation index were analyzed. Results DAT was positive and DAT typingshowed IgG+C3, and antibodies against cephalosporins was present in theserumof the patient, the Hb decreased from 122g / L to 80g / L after treatment and the PLT from 90×10⁹/ L to 17×10⁹/L. Inversely, LDH increased from 189.5 μmol / L to 347.2 μmol / L and AST increased from 25.7 U / L to 63.5 U / L. PT prolonged from 13.4 s to 20.9 s and APTT from 35.8 s to 56.6 s, with the INR extending from 1.19 to 1.8. Conclusion Hemolytic anemiamay occurin the patient following cefoperazone-sulbactam sodium administration.

Key words: Cefoperazone-sulbactam sodium, Hemolytic anemia, Anti-human globulin test, Antibodies against drug