Abstract: Objective To explore the value of thinprep cytology test （TCT） and human papilloma virus （HPV） test in cervical intraepithelial neoplasia （CIN） screening. Methods A retrospective analysis was performed by using the data of 674 patients with neoplasia from 2012 to 2015,and all patients received TCT and HPV tests and confirmed diagnoses were made by biopsy. Results Five hundred and seventy eight of 674 cases received TCT tests and 508 cases received HPV tests. TCT or HPV tests were positive in 509 （88.1%） and 459 cases （90.4%）,respectively. Three hundred and fifty of 444 cases （78.8%） were found to have overlaped positivity,and 90 cases were TCT positive （20.3%）,with general positive rate of 99.1%. The results showed that a combined testing gives rise to a higher positive rate than the single test（P<0.05）although no significant difference was noted between TCT and HPV（P>0.05）. Conclusion Combination tests of both TCT and HPV may improve the efficacy and avoid missed diagnosis in CIN screening.

Key words: Cervical intraepithelial neoplasia, Liquid based cytology test, Human papilloma virus, Test value