Abstract: Objective To explore the correlation of serum growth differentiation factor-15 （GDF-15） and soluble haemoglobin scavenger receptor （sCD163） in patients with type 2 diabetic nephropathy （DN）. Method A total of 106 patients with type2 diabetes mellitus in the hospital were selected from February 2014 to June 2016 and the subjects were divided into normal albuminuria （n=32）,micro-albuminuria（n=35） and macro-albuminuria groups（n=39） according to Mogensen staging criteria.Additional 40 cases of healthy peoplewere takenas control. The levels of serum GDF-15 and sCD163 were determined by enzyme-linked immunosorbent assay（ELISA）,and the correlations with common clinical index were analyzed. Results The levels of GDF-15 and sCD163 in DN group weresignificantly higher than those of control group,and increased gradually with the progress of diabetic nephropathy. Conclusion analysis showed that GDF-15 and sCD163 werepositively correlated with diabetic durationsand levels of FPG,HbAlc,LDL-c,TC,TG,UAER,BUN and Cr （P<0.05 or P<0.01）,but negatively correlated with HDL-C （P<0.01）. Conclusion The levels of serum GDF-15 and sCD163are elevated and GDF-15 and sCD163 are closely related to the occurrence and development of type 2 diabetic nephropathy.

Key words: Growth differentiation factor-15, Soluble hemoglobin scavenger receptor, Type 2 diabetic, nephropathy