Abstract: Objective To analyze the relationship between serum uric acid level and urinary albumin/urinary creatinine(UACR), and to evaluate the serum uric acid level in predicting the occurrence of diabetic kidney disease (DKD) in patients with type 1 diabetic mellitus. Methods Based on retrospectively cross-sectional study method,186 cases of type 1 diabetic mellitus were enrolled who were treated in the hospital from August 2015 to December 2017. The patients were divided into three groups according to UACR: non-diabetic nephropathy group (n=117), micro-albuminuria group（n=47）,and macro-albuminuria group (n=22). Results The serum uric acid level in macro-albuminuria group was higher than that in non-diabetic nephropathy group (P<0.05). The serum uric acid level had the positive correlation with the gender, body mass index, systolic pressure, serum creatinine, blood urea nitrogen and triglyceride. Logistic regression analysis showed that HbA1c and serum uric acid were independent risk factors of DKD. Conclusions The serum uric acid is the independent risk factor of diabetes kidney disease in patients with type 1 diabetic mellitus.

Key words: Type 1 diabetes mellitus, Uric acid, Diabetic nephropathy, Risk factors