Abstract: Objective To explore serum levels of Ang Ⅱ, BNP and neutrophil-to-lymphocyte ratio（NLR） in patients with chronic heart failure （CHF） before and after treatment and the clinical value of combination detection for CHF patients. Methods 120 cases of patients with CHF in our hospital from January 2016 to December 2018 were selected as CHF group. The patients were divided into different cardiac function groups according to NYHA method including grade Ⅱ with 48 cases, grade Ⅲ with 39 cases and grade Ⅳ with 33 cases. 95 cases healthy volunteers were selected as control group. The serum AngⅡ, BNP and NLR of all the subjects were detected, and the results were analyzed statistically. Results The levels of serum AngⅡ, BNP and NLR in CHF group before treatment were higher than those of control group, and the differences were statistical significance(P<0.05).The levels of serum AngⅡ, BNP and NLR in CHF patients were all increased along with the severity of the disease, and there were statistically significant difference in AngⅡ, BNP and NLR levels between each two groups(P<0.05). After treatment, the levels of serum AngⅡ, BNP and NLR in CHF were significantly decreased (P<0.05). The areas under the curve (ROC) of AngⅡ, BNP and NLR for distinguishing CHF from all control individuals were 0.83、0.84、0.75 respectively. Pearson correlation analysis showed that NLR and Ang Ⅱ closely related (r=0.483, P< 0.05); NLR was positively correlated with BNP (r=0.527, P<0.05). Conclusions The levels of AngⅡ, BNP and NLR in CHE were changed significantly before and after treatment and may be help for cardiac function grading and diagnosis,and the combined detection of those parameters could improve the accuracy of CHF diagnosis.

Key words: AngⅡ, Neutrophil-to-lymphocyte ratio, Brainnatriuretic peptide, Chronic heart failure