Abstract: ObjectiveTo study the influence of traumatic hemorrhagic shock（THS）on antioxidant enzymes. MethodsThe model of the THS with gradient decrease of the systolic blood pressure was etablished in 11 Newzealand rabbits.The arterial blood pressures in the different time following THS were measured with the systolic pressures of 2/3（T2）,1/2（T3）,and 1/3（T4）of the basic systolic blood pressure Superoxide dismutase（SOD）,hydrogen peroxide enzyme（CAT）,and glutathione oxidation reductase（GSH-Px）levels in the plasma were determined by the double antibody sandwich method of enzyme-labeled immunosorbent assay（ELISH）. ResultsT-SOD：The levels of the antioxidant enzymes were lower in Group A than in group B; group B was higher than group C; and group C was higher than group D. There was no significant difference between the time level（P>0.05）.In CAT detection,it was higher in Group A than in group B,group B was higher than group C,group C was higher than group D,there was no significant difference between the T1-T2,T2-T3,and T3-T4（P>0.05）. The significant difference,however,was noted between the other groups（P <0.05）. In GSH-Px tests,Group A was found to be higher than group B,group B was higher than group C,group C was higher than group D,there was no significant difference between the T1 and T2（P>0.05）,and A significant difference was seen between the other groups（P<0.05）. ConclusionWhen the systolic blood pressure decline curve was used for THS and antioxidant detection in rabbits,THS has a significant affect on the antioxidant enzyme systemshowing a significant decrease of CAT,GSH-Px and SOD,and activity decreased. Blood loss coincides with decrease of CAT and GSH-Px on THS.

Key words: Traumatic, Hemorrhagic, shock, Lipid, peroxidation, Antioxidant, enzyme, Superoxide, dismutase, Hydrogen, peroxide, enzyme, Glutathione, oxidation, reductase