Abstract: Objective To evaluate the prognostic value of plasma homocysteine （Hcy） in patient with acute heart failure （AHF）. Methods From January 2018 to February 2019, 65 hospitalized patients with AHF or cardiac function capacity Ⅳ in Chaohu affiliated hospital of Anhui medical universty were selected as heart failure （HF） group, 65 patients without HF as control group at the same time. The above patients underwent plasma Hcy detection and echocardiography when they were admitted and were followed up for 6 months. Results Hcy plasma levels were significantly higher in AHF group than in control group. Hcy plasma levels were significantly positively associated with left ventricular end-diastolic diameter（LVEDD）, negatively with left ventricular ejection fraction （LVEF） and short axis shortening rate （FS）. In this study, 5 patients died and other 34 were readmitted within 6 months. 7 of which were readmitted due to cardiovascular events. 26 cases had satisfactory cardiovascular function controlled and no adverse events. Hcy levels were significantly higher in patients readmitted or died within 6 months than in patients without adverse events. Conclusion Hcy Plasma levels have good prognostic value for patients with AHF. Hcy is closely related to clinical and echocardiographic data, severity of HF and adverse outcomes.

Key words: Acute, heart, failure, Homocysteine, Prognosis