Abstract: Objective To investigate the related factors associated with blood product and its dose in unrelated umbilical cord blood transplantation (UCBT) patients. Methods The blood transfusion data of 29 patients with hematologic diseases undergoing UCBT were reviewed. The patients were divided into two groups: low dose group, a total of red blood cell (RBC) transfusions and platelet transfusions <18 U; high dose group, a total of RBC transfusions and platelet transfusions ≥18 U. The relationship between pre-transplant clinical data, implantation after transplantation, the incidence of acute graft-versus-host disease（aGVHD）, one-year survival rate and blood transfusion were analyzed. Results The average volume of transfused RBCs in 29 patients within 60 days after transplantation was (10.97±11.80) U, and the average volume of transfused platelets was (7.12±5.06) U. There was a significant positive correlation between platelet and RBC transfusions. There was no significant difference in clinical data between the two groups before transplantation. There was a positive correlation between time of neutrophils implantation and platelet transfusions volume (P<0.05). RBC and platelet transfusions in patients with grade Ⅱ~Ⅳ aGVHD after transplantation were significantly higher than those in patients with grade 0 ~Ⅰ acute GVHD. The one-year survival rate in low dose group was significantly higher than that in high dose group (P <0.05). Conclusion The volume of RBC and platelet transfusions in UCBT patients within 60 days after transplantation was significantly correlated with donor implantation, aGVHD and survival after transplantation.

Key words: Unrelated umbilical cord blood transplantation, Leukemia, Red blood cell transfusion, Platelet transfusion, Acute graft versus host disease