Abstract: Objective To observe the levels of serum homocysteine（Hcy） in the patients with maintenance hemodialysis （MHD）,and analysis of the affected factors related to homocystein. Methods There were 82 patients with maintenance hemodialysis （The dialysis duration is more than 3 months） were selected for this study. They were divided into high homocysteine group （59 cases,Hcy≥15μmol/L） and low homocysteine group （23 cases,Hcy<15μmol/L） according to the levels of serum homocysteine. The differences of biochemical index between the low homocysteine group and the high homocysteine group were compared, and the affected factors related to homocystein were analysed by Pearson correlation analysis/Logistic regression analysis. Result ①The average of the serum homocysteine is （42.15±7.28） μmol/L and the proportion of high homocysteine is 72%. ② Compared with the low homocysteine group,the levels of albumin, hemoglobin, high density lipoprotein and calcium in the high homocysteine were significantly decreased, but the levels of Low density lipoprotein, Fasting plasma glucose, Blood uric acid, Systolic blood pressure and Diastolic blood pressure were significantly increased. ③ Pearson linear correlation analysis show that the levels of homocysteine are positively correlation with the Low density lipoprotein, Fasting plasma glucose Blood uric acid, Systolic blood pressure and Diastolic blood pressure,while are negatively correlation with the albumin, high density lipoprotein and hemoglobin. Logistic regression analysis showed that albumin and hemoglobin were protective factors for homocysteine and the Low density lipoprotein, Fasting plasma glucose, Blood uric acid, Systolic blood pressure and Diastolic blood pressure were hazards factors for homocysteine. Conclusions The incidence of high homocysteine in patients with MHD was high;the albumin and hemoglobin were protective factors and the Low density lipoprotein, Fasting plasma glucose, Blood uric acid, Systolic blood pressure and Diastolic blood pressure were hazards factors for homocysteine.

Key words: Maintenance Hemodialysis, Homocysteine, Chronic kidney disease, Correlation