Abstract: Objective To investigate the correlation of the tumor markers Cyfra21-1,NSE,CEA and CA125 in the patients of lung cancers with the bone metastasis （PLCM）. Methods Seventy-three patients with bone metastasis of lung cancers were selected in 2016 and 106 cases of lung cancers without bone metastasis were taken as control for examinations of ECT,Cyfra21-1,NSE,CEA,CA125 .The levels of the markers were compared based on the focus number of bone metastasis and pathology types. Results The PLCM group had a significantly high level of Cyfra21-1,NSE,CEA,and CA125 compared with those without the metastasis （P<0.05） but no difference of the positive rates was seen in any single marker test（P>0.05）. The combined test of those markers,however,obviously increased the positive rates from 38.68% of the control to 80.82% of the PLCM（P<0.05）. The incidence of bone metastasis went in parallel with high level of the serum markers（P<0.05）while no statistic difference of the markers was noted among the patients with osteolytic and osteoblastic metastasis and mixed type of metastasis（P>0.05）.Conclusion The increased level of Cyfra21-1,NSE,CEA,and CA125 is closely associated with bone metastasis and corresponds with the number of metastatic foci but not with the pathological types of lung cancers,suggesting that it might be useful for evaluation and prediction of bone metastasis in the patients with lung cancers .

Key words: Tumor markers, Lung cancer bone metastasis, ECT, Correlation typing