Abstract: Objective To investigate the transfusion strategy and prognostic effectiveness of hemolytic disease of the fetus and newborn（HDFN）caused by anti-D antibody. Methods Ten patients diagnosed with HDFN due to anti-D antibody at our hospital between January 2015 and December 2019 were enrolled,all of whom were treated with compatible blood. Changes in blood routine indexes and blood biochemical indexes before and after treatment were observed. Results The values of Hb,RBC and Hct before treatment were（104.70±3.72）g/L,（3.01±0.14）×10¹²/L,（0.33±0.01）%,and these values after treatment were（136.60±2.40）g/L,（4.09±0.17）×10¹²/L,（0.40±0.01）%,respectively. The indexes after treatment was significantly better than those before treatment（P<0.05）. The values of TBL,DBL,IBL and LDH before treatment were（294.09±26.91）mol/L,（25.68±3.84）mol/L,（268.41±24.16）mol/L,（591.60±59.69）IU/L,and these values after treatment were（164.86±25.4）mol/L,（16.03±1.86）mol/L,（143.41±24.3）mol/L,（347.20±33.82）IU/L,respectively. The indexes after treatment was significantly better than those before treatment（P<0.05）. Conclusion When a transfusion is given,it is preferable for patients with HFDN to receive blood of the same ABO and RhD negative type,and its clinical effect after transfusion is good.

Key words: Anti-D antibody, Hemolytic disease of newborn, Compatible transfusion, Therapeutic effect of blood transfusion