Abstract: Objective To investigate the diagnostic value of serum homocysteine （Hcy）,lipoprotein a （LPa） and lipoprotein phospholipase A2 （LP-PLA2） detection in coronary heart disease. Methods A total of 214 CHD patients admitted to our hospital from March 2016 to March March 2018 were selected as observation group. According to the disease type,82 patients with acute myocardial infarction were treated as group A and 74 patients with stable angina were treated as group B. 58 Cases with unstable angina were treated as group C,and another 180 patients without coronary heart disease in our hospital during the same period were selected as control group. Serum levels of Hcy,LPa,and LP-PLA2 were measured in each group,and comparative analysis was performed. The positive rates of single-marker detection and combined detection were compared. The range of serum Hcy,LPa,and LP-PLA2 indicators was also compared in each group.Results The positive rates of serum Hcy,LPa,and LP-PLA2 detection and combined detection in group A,B,and C were higher than those in the control group,and the difference was statistically significant （P<0.05）. The levels of serum Hcy,LPa,and LP-PLA2 were positive and positive in the groups A and C. The rate was higher in group B than in group B （P<0.05）. The positive rates of serum Hcy,LPa,and LP-PLA2 in group A,B,and C were higher than those in serum Hcy,LPa,and LP-PLA2 alone. Statistical significance （P<0.05）; Serum Hcy level in group A was higher than that in group B and control group,the difference was statistically significant （P<0.05）; LPA,LP-PLA2 levels in group A,B,and C were higher than those in control group The difference was statistically significant （P<0.05）; there was a clear line between the LPA levels in the A,B,and C groups,and there was a clear line between the LP-PLA2 levels in the B and C groups.Conclusion The combined detection of serum Hcy,LPa,and LP-PLA2 levels has significant value in the diagnosis of coronary heart disease. LPa and LP-PLA2 levels can effectively distinguish the type of coronary heart disease,and it is worth promoting.

Key words: Homocysteine, Lipoprotein a, Lipoprotein phospholipase A2, Diagnosis of coronary heart disease