Abstract: Objective To study the correlation between serum epidermal cell-type fatty acid binding protein (E-FABP) and serum fibroblast growth factor 21 (FGF-21) and glucose and lipid metabolic indicators in patients with polycystic ovary syndrome. Methods 74 patients with polycystic ovary syndrome admitted to our hospital from April 2017 to March 2018 were enrolled. According to BMI, they were divided into obese group (n=43) and non-obese group (n=31), and 36 healthy subjects with similar BMI to patients in the same period were selected as the control group. The serum levels of FGF-21, E-FABP, glucose metabolism and lipid metabolism in the three groups were observed and compared. Results The serum FGF-21 and E-FABP levels of the obese group and the non-obese group were significantly higher than those of the control group (P<0.05), and the serum FGF-21 and E-FABP levels of the obese group were significantly higher than those of the non-obese group (P<0.05). The glucose metabolism level of the non-obese group and the obese group was significantly higher than that of the control group (P<0.05), and the glucose metabolism level of the obese group was significantly higher than that of the non-obese group (P<0.05). Non-obese group and obesity group patients LDL - C, FFA, TC and TG levels are significantly higher than control group (P<0.05), level of HDL - C in non-obese group and obesity group was obviously lower than that in the control group (P<0.05), LDL - C, FFA, TC and TG levels are significantly higher in obese patients than non-obese patients (P<0.05), HDL - C levels in patients with obesity group was obviously higher than non-obese patients (P<0.05); According to the data analysis, the serum FGF-21 and E-FABP levels were directly correlated with the glycolipid metabolism indicators (P<0.05). Conclusion According to the findings of this study, the serum levels of FGF-21 and E-FABP in patients with polycystic ovary syndrome can reflect the changes of patients' glucose and lipid metabolism, which is worthy of promotion and application.

Key words: Polycystic ovarian syndrome, Glycolipid metabolism index, Serofibroblast growth factor 21, Serum epidermal cell fatty acid binding protein