Abstract: Objective To investigate the current situation of anti-mullerian hormone （AMH） in healthy women of healthy childbearing age in Baoan district Shenzhen city，and to explore its application value in PCOS and POF treatment. Method We collected health check-up healthy women of childbearing age 1 200 cases as control group in March 2016 to May 2017 in Shenzhen baoan district maternity and child care，and selected polycystic ovarian syndrome（PCOS）patients 85 cases and premature ovarian failure（POF）patient 67 cases at the same period，detected the serum AMH level of Control group，patients with PCOS and POF group at before the treatment and after 3-months treatment respectively，and analyzed the testing results. Results The serum AMH level of 1 200 cases of healthy women of childbearing age was 4.97±1.64 ng/ml，19～25 years old group was 5.41±1.38 ng/ml，significantly higher than 31～35 and 36～41 years old group，was statistically significant difference （t=3.092～5.126，P<0.05），compared with 26～30 years old group （5.07±1.52 ng/ml） there was no statistically significant difference （t=0.906，P>0.906）. Before the treatment，the serum AMH level of patients with PCOS was 9.76±3.82 ng/ml，significantly higher than the control group，POF and wait POF group，difference was statistically significant （t=13.294～13.294，P<0.01～0.001）; the serum AMH level of POF patients was 0.94±0.36 ng/ml，significantly lower than the control group and wait POF group，difference was statistically significant （t=2.915～2.915，P<0.05）; the serum AMH level of wait patients was 2.37±0.82 ng/ml，significantly lower than the control group，the difference was statistically significant （t=8.604，P<0.05）. After treatment，the serum AMH level of PCOS，POF and wait POF patients were 5.29±1.62 ng/ml，4.25±1.24ng/ml and 4.51±1.50 ng/ml，and the difference was statistically significant between before treatment （t=7.672～11.057，P<0.05），compared with the control group there were no statistically significant differences （t=0.790～1.527，P>0.05）. Conclusion The serum AMH levels of PCOS patients were significantly higher in before treatment，and the serum levels of POF and wait POF patients were significantly reduced，while the serum AMH levels of PCOS，POF and wait POF patients were all restored to normal levels after treatment. Therefore，AMH has certain application value in the diagnosis and treatment evaluation of women PCOS and POF disease.

Key words: Women of childbearing age, Anti-Mullerian hormone, Current situation, Polycystic ovary syndrome, Premature ovarian failure Value