Abstract: Objective To investigate the correlation between the serum levels of AFP-L3%,CA125,CA199 and IL-6 and HBV induced liver cirrhosis and hepatocellular carcinoma.Methods Forty-five patients with chronic hepatitis B,41 patients with post-hepatitis B cirrhosis and 24 patients with hepatitis B-related liver cancer were selected as the study group,and 30 healthy persons were selected as the control group. Serum levels of AFP-L3%,CA125,CA199 and IL-6 were detected and compared.Results Compared with the control group,the levels of AFP-L3%,CA125,CA199 and IL-6 in chronic hepatitis B group,liver cirrhosis group and liver cancer group were significantly increased （P<0.05）. With the development of the disease,AFP-L3% and IL-6 levels in chronic hepatitis B group,liver cirrhosis group and liver cancer group increased gradually. IL-6 （91.67%） was the most sensitive and AFP-L3% （89.66%） was the most specific. The sensitivity,specificity and accuracy of the four combined tests were higher than those of single test.Conclusion sSerum AFP-L3%,CA125,CA199 and IL-6 levels were correlated with liver cirrhosis and canceration caused by hepatitis B,and the combined detection of four serum indicators could improve the diagnostic efficiency of liver cancer B and make up for the defect of single detection.

Key words: AFP-L3%, CA125, CA199, IL-6, Liver cancer