Abstract: Objective To explore the clinical significance of serum HE4 combined with CA125 detections in early diagnosis and prognosis in evaluation of ovarian cancer. Methods Seventy-two cases of colon cancer treated in hospital from January 2014 to April 2015 were followed up,and serum HE4 and CA125 were jointly detected. The expression of CA125 and HE4 in the patients with single or combined tests was compared, and the pathological changes and survival duration of the patients were analyzed for the clinical significance of HE4 with CA125 detection in early diagnosis and prognosis evaluation of ovarian cancer. Results Serum HE4 and CA125 levels were significantly higher in ovarian cancer patients（P<0.05） compared with the normal. Sensitivity,specificity,positive or negative predictive rate were obviously lower in HE4 or CA125 single test. The combined tests of HE4 and CA125 gave rise to a low missed diagnosis and a high Youden index（P<0.05）. The motality of patients treated under orientation of both HE4 combined with CA 125 detection was significantly less than that of the single detection（P<0.05）. Conclusion Serum HE4 combined with CA125 detection can effectively predict the survival lenghth of patients,and has a high clinical value.

Key words: Serum HE4, Serum CA125, Ovarian carcinoma, Prognosis evaluation, Early diagnosis